%0 Journal Article
%A Schorling, Constantin
%A Rauth, Evelyn
%A Stengl, Christina
%A Seco, Joao
%T Experimental investigation of oxygen diffusion in the peak and valley region of minibeam patterns during x-ray irradiation.
%J Medical physics
%V 52
%N 8
%@ 0094-2405
%C Hoboken, NJ
%I Wiley
%M DKFZ-2025-01660
%P e17999
%D 2025
%Z #EA:E041#LA:E041#
%X Minibeam radiotherapy has demonstrated its potential to reduce normal tissue toxicity while maintaining tumor control. However, the underlying mechanisms behind this phenomenon remain unknown. Recent theoretical studies suggest a dose surrogate by diffusion of H 2 O 2 H<sub>2</sub>O<sub>2</sub> into the valley regions.The aim of this study is to experimentally investigate oxygen depletion and diffusion upon minibeam (MB) irradiation.A 3D-printed water phantom with four sensors was developed to enable the real-time, simultaneous measurement of oxygen concentration in the peak and valley. Water with 0
%K Oxygen: metabolism
%K Diffusion
%K X-Rays
%K Phantoms, Imaging
%K Water: chemistry
%K minibeam irradiation (Other)
%K oxygen depletion measurements (Other)
%K spatial fractionation (Other)
%K Oxygen (NLM Chemicals)
%K Water (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40781834
%2 pmc:PMC12334874
%R 10.1002/mp.17999
%U https://inrepo02.dkfz.de/record/303447