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000303447 0247_ $$2ISSN$$a2473-4209
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000303447 1001_ $$0P:(DE-He78)546d469c1c6d01f821696cc15db2ed4e$$aSchorling, Constantin$$b0$$eFirst author$$udkfz
000303447 245__ $$aExperimental investigation of oxygen diffusion in the peak and valley region of minibeam patterns during x-ray irradiation.
000303447 260__ $$aHoboken, NJ$$bWiley$$c2025
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000303447 520__ $$aMinibeam radiotherapy has demonstrated its potential to reduce normal tissue toxicity while maintaining tumor control. However, the underlying mechanisms behind this phenomenon remain unknown. Recent theoretical studies suggest a dose surrogate by diffusion of H 2 O 2 ${\rm H}_2{\rm O}_2$ into the valley regions.The aim of this study is to experimentally investigate oxygen depletion and diffusion upon minibeam (MB) irradiation.A 3D-printed water phantom with four sensors was developed to enable the real-time, simultaneous measurement of oxygen concentration in the peak and valley. Water with 0%-11% O 2 ${\rm O}_2$ and 0.1%/5.0% CO 2 ${\rm CO}_2$ was irradiated with broad beam (BB) and MB characterized by peak and valley widths of 2 mm × $\times$ 2 mm and 0.5 mm × $\times$ 2 mm. The depletion was further compared in other chemical environments.The oxygen depletion rates per dose in hypoxic water in the valley regions were found to be 3-7 times higher compared to the peaks or BB. This observation was found to be independent of oxygen concentration above 2 %, indicating oxygen depletion saturation. For MB, diffusion between peaks and valleys was observed. After a certain period, an equilibrium between diffusion and dose rate differences was established. Glutathione and HEPES as a medium increased the depletion further and distinguished MB from BB.A novel way of simultaneously measuring oxygen in the peak and valley of the MB dose pattern was introduced. The observed oxygen depletion saturation and diffusion between the peaks and valleys suggest the importance of oxygen in spatially fractionated radiotherapy studies, which is even greater for 5 mM glutathione compared to water.
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000303447 650_7 $$2Other$$aminibeam irradiation
000303447 650_7 $$2Other$$aoxygen depletion measurements
000303447 650_7 $$2Other$$aspatial fractionation
000303447 650_7 $$0S88TT14065$$2NLM Chemicals$$aOxygen
000303447 650_7 $$0059QF0KO0R$$2NLM Chemicals$$aWater
000303447 650_2 $$2MeSH$$aOxygen: metabolism
000303447 650_2 $$2MeSH$$aDiffusion
000303447 650_2 $$2MeSH$$aX-Rays
000303447 650_2 $$2MeSH$$aPhantoms, Imaging
000303447 650_2 $$2MeSH$$aWater: chemistry
000303447 7001_ $$0P:(DE-He78)2dcfd964503806e96ccd1124c5beadf8$$aRauth, Evelyn$$b1$$udkfz
000303447 7001_ $$0P:(DE-He78)5d3fd2061719ec17ba3c894c81dbde89$$aStengl, Christina$$b2$$udkfz
000303447 7001_ $$0P:(DE-He78)102624aca75cfe987c05343d5fdcf2fe$$aSeco, Joao$$b3$$eLast author$$udkfz
000303447 773__ $$0PERI:(DE-600)1466421-5$$a10.1002/mp.17999$$gVol. 52, no. 8, p. e17999$$n8$$pe17999$$tMedical physics$$v52$$x0094-2405$$y2025
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