TY  - JOUR
AU  - Schorling, Constantin
AU  - Rauth, Evelyn
AU  - Stengl, Christina
AU  - Seco, Joao
TI  - Experimental investigation of oxygen diffusion in the peak and valley region of minibeam patterns during x-ray irradiation.
JO  - Medical physics
VL  - 52
IS  - 8
SN  - 0094-2405
CY  - Hoboken, NJ
PB  - Wiley
M1  - DKFZ-2025-01660
SP  - e17999
PY  - 2025
N1  - #EA:E041#LA:E041#
AB  - Minibeam radiotherapy has demonstrated its potential to reduce normal tissue toxicity while maintaining tumor control. However, the underlying mechanisms behind this phenomenon remain unknown. Recent theoretical studies suggest a dose surrogate by diffusion of H 2 O 2 H<sub>2</sub>O<sub>2</sub> into the valley regions.The aim of this study is to experimentally investigate oxygen depletion and diffusion upon minibeam (MB) irradiation.A 3D-printed water phantom with four sensors was developed to enable the real-time, simultaneous measurement of oxygen concentration in the peak and valley. Water with 0
KW  - Oxygen: metabolism
KW  - Diffusion
KW  - X-Rays
KW  - Phantoms, Imaging
KW  - Water: chemistry
KW  - minibeam irradiation (Other)
KW  - oxygen depletion measurements (Other)
KW  - spatial fractionation (Other)
KW  - Oxygen (NLM Chemicals)
KW  - Water (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40781834
C2  - pmc:PMC12334874
DO  - DOI:10.1002/mp.17999
UR  - https://inrepo02.dkfz.de/record/303447
ER  -