000303449 001__ 303449
000303449 005__ 20250817022056.0
000303449 0247_ $$2doi$$a10.1038/s41388-025-03530-w
000303449 0247_ $$2pmid$$apmid:40781158
000303449 0247_ $$2ISSN$$a0950-9232
000303449 0247_ $$2ISSN$$a1476-5594
000303449 0247_ $$2altmetric$$aaltmetric:180236756
000303449 037__ $$aDKFZ-2025-01662
000303449 041__ $$aEnglish
000303449 082__ $$a610
000303449 1001_ $$00000-0003-4147-7051$$aZou, Xiaoping$$b0
000303449 245__ $$aALDH1A3 promotes aggressive basal-like pancreatic cancer through an AP-1/RUNX2 enhancer network.
000303449 260__ $$aLondon$$bSpringer Nature$$c2025
000303449 3367_ $$2DRIVER$$aarticle
000303449 3367_ $$2DataCite$$aOutput Types/Journal article
000303449 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1754912891_16539
000303449 3367_ $$2BibTeX$$aARTICLE
000303449 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000303449 3367_ $$00$$2EndNote$$aJournal Article
000303449 500__ $$aepub
000303449 520__ $$aThe basal-like transcriptional subtype of pancreatic ductal adenocarcinoma (PDAC) is linked to therapy resistance and poor prognosis. The cancer stem cell marker aldehyde dehydrogenase 1A3 (ALDH1A3) is a critical enzyme in acetaldehyde metabolism, but the interconnection to the basal-like subtype is poorly understood. Here, we identified ALDH1A3 as a key gene, which correlates with reduced survival and increased tumor growth. Functional studies revealed interaction of ALDH1A3 with genes like FAM3C, MCC, PMEPA1, and IRS2, forming a network driving PDAC progression. Chromatin profiling showed that ALDH1A3 affects acetylation of histone 3, mediating AP-1 activity, particularly via FOS family members, activating oncogenic pathways such as MAPK and TNF signaling. RUNX2 emerged as a therapeutic target within this network, as its knockdown disrupted MAPK signaling and reduced tumor growth. These findings emphasize the role of ALDH1A3 in linking nuclear metabolic-epigenetic programming in basal-like PDAC, highlighting it as a promising therapeutic target for novel treatment strategies.
000303449 536__ $$0G:(DE-HGF)POF4-319H$$a319H - Addenda (POF4-319H)$$cPOF4-319H$$fPOF IV$$x0
000303449 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000303449 7001_ $$aNie, Shuang$$b1
000303449 7001_ $$aCao, Jing$$b2
000303449 7001_ $$aShi, Mengyue$$b3
000303449 7001_ $$aSchuck, Kathleen$$b4
000303449 7001_ $$aShi, Zhao$$b5
000303449 7001_ $$aZhang, Lingling$$b6
000303449 7001_ $$aLi, Hongzhen$$b7
000303449 7001_ $$aSun, Yifeng$$b8
000303449 7001_ $$aFang, Chao$$b9
000303449 7001_ $$aHu, Jingxiong$$b10
000303449 7001_ $$aNiu, Yiqi$$b11
000303449 7001_ $$aYu, Yuanyuan$$b12
000303449 7001_ $$aZhang, Zhiheng$$b13
000303449 7001_ $$aLi, Chao$$b14
000303449 7001_ $$aHu, Mingyue$$b15
000303449 7001_ $$aWang, Lei$$b16
000303449 7001_ $$00000-0002-2849-5450$$aJiang, Kuirong$$b17
000303449 7001_ $$aLu, Zipeng$$b18
000303449 7001_ $$aAkkan, Jan$$b19
000303449 7001_ $$aRaulefs, Susanne$$b20
000303449 7001_ $$aKahlert, Christoph$$b21
000303449 7001_ $$aRoth, Susanne$$b22
000303449 7001_ $$aHerr, Ingrid$$b23
000303449 7001_ $$aWan, Yuan$$b24
000303449 7001_ $$aMihaljevic, Andre$$b25
000303449 7001_ $$aQian, Xuetian$$b26
000303449 7001_ $$aZhang, Qi$$b27
000303449 7001_ $$00000-0003-1223-4595$$aWang, Maggie Haitian$$b28
000303449 7001_ $$aKleeff, Jörg$$b29
000303449 7001_ $$aFriess, Helmut$$b30
000303449 7001_ $$0P:(DE-He78)73316f3cd41c27508dbb6f4c5e7e7a8a$$aGu, Zuguang$$b31
000303449 7001_ $$aMichalski, Christoph W$$b32
000303449 7001_ $$00009-0000-7889-5674$$aShen, Shanshan$$b33
000303449 7001_ $$00009-0007-4997-8009$$aKong, Bo$$b34
000303449 773__ $$0PERI:(DE-600)2008404-3$$a10.1038/s41388-025-03530-w$$pnn$$tOncogene$$vnn$$x0950-9232$$y2025
000303449 909CO $$ooai:inrepo02.dkfz.de:303449$$pVDB
000303449 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)73316f3cd41c27508dbb6f4c5e7e7a8a$$aDeutsches Krebsforschungszentrum$$b31$$kDKFZ
000303449 9131_ $$0G:(DE-HGF)POF4-319H$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vAddenda$$x0
000303449 9141_ $$y2025
000303449 915__ $$0StatID:(DE-HGF)3002$$2StatID$$aDEAL Springer$$d2024-12-27$$wger
000303449 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bONCOGENE : 2022$$d2024-12-27
000303449 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2024-12-27
000303449 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2024-12-27
000303449 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2024-12-27
000303449 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2024-12-27
000303449 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2024-12-27
000303449 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2024-12-27
000303449 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2024-12-27
000303449 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2024-12-27
000303449 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2024-12-27
000303449 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2024-12-27
000303449 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2024-12-27
000303449 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bONCOGENE : 2022$$d2024-12-27
000303449 9201_ $$0I:(DE-He78)W610-20160331$$kW610$$lCore Facility Omics IT$$x0
000303449 980__ $$ajournal
000303449 980__ $$aVDB
000303449 980__ $$aI:(DE-He78)W610-20160331
000303449 980__ $$aUNRESTRICTED