TY  - JOUR
AU  - Rinne, Sanni
AU  - Michels, Birgitta
AU  - Butt, Julia
AU  - Syrjänen, Kari
AU  - Grenman, Seija
AU  - Waterboer, Tim
AU  - Syrjänen, Stina
AU  - Louvanto, Karolina
TI  - Epstein-Barr virus (EBV) serology and its impact on oral human papillomavirus (HPV) infection outcomes in children during early childhood.
JO  - Microbiology spectrum
VL  - 13
IS  - 9
SN  - 2165-0497
CY  - Birmingham, Ala.
PB  - ASM
M1  - DKFZ-2025-01670
SP  - e0007125
PY  - 2025
N1  - 2025 Sep 2;13(9):e0007125
AB  - Epstein-Barr virus (EBV) and various human papillomaviruses (HPVs) commonly infect the oral mucosa, yet the longitudinal effects of these infections and their potential coinfections remain poorly understood. This study investigated whether early EBV infection and antibody responses influence oral HPV infections in young children. We included 283 children from the Finnish Family HPV cohort study, who were followed for 3 years post-birth. Oral and blood samples were collected at six time points (1, 2, 6, 12, 24, and 36 months). HPV genotyping was performed with Luminex and EBV-IgG antibodies to Zebra, early antigen-diffuse (EA-D), EBV nuclear antigen 1, and viral capsid antigen p18 with fluorescent bead-based multiplex serology. We noticed that most children (91.4
KW  - EBV serology (Other)
KW  - Epstein-Barr virus (Other)
KW  - children (Other)
KW  - human papillomavirus (Other)
KW  - oral HPV infection (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40748074
DO  - DOI:10.1128/spectrum.00071-25
UR  - https://inrepo02.dkfz.de/record/303473
ER  -