000303496 001__ 303496
000303496 005__ 20250817022126.0
000303496 0247_ $$2doi$$a10.1038/s41586-025-09389-x
000303496 0247_ $$2pmid$$apmid:40804518
000303496 0247_ $$2ISSN$$a0028-0836
000303496 0247_ $$2ISSN$$a1476-4687
000303496 0247_ $$2altmetric$$aaltmetric:180267545
000303496 037__ $$aDKFZ-2025-01687
000303496 041__ $$aEnglish
000303496 082__ $$a500
000303496 1001_ $$00000-0002-9728-1413$$aTonnus, Wulf$$b0
000303496 245__ $$aMultiple oestradiol functions inhibit ferroptosis and acute kidney injury.
000303496 260__ $$aLondon [u.a.]$$bNature Publ. Group$$c2025
000303496 3367_ $$2DRIVER$$aarticle
000303496 3367_ $$2DataCite$$aOutput Types/Journal article
000303496 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1755242046_8667
000303496 3367_ $$2BibTeX$$aARTICLE
000303496 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000303496 3367_ $$00$$2EndNote$$aJournal Article
000303496 500__ $$aDKFZ-ZMBH Alliance / epub
000303496 520__ $$aAcute tubular necrosis mediates acute kidney injury (AKI) and nephron loss1, the hallmark of end-stage renal disease2-4. For decades, it has been known that female kidneys are less sensitive to AKI5,6. Acute tubular necrosis involves dynamic cell death propagation by ferroptosis along the tubular compartment7,8. Here we demonstrate abrogated ferroptotic cell death propagation in female kidney tubules. 17β-oestradiol establishes an anti-ferroptotic state through non-genomic and genomic mechanisms. These include the potent direct inhibition of ferroptosis by hydroxyoestradiol derivatives, which function as radical trapping antioxidants, are present at high concentrations in kidney tubules and, when exogenously applied, protect male mice from AKI. In cells, the oxidized hydroxyoestradiols are recycled by FSP19,10, but FSP1-deficient female mice were not sensitive to AKI. At the genomic level, female ESR1-deficient kidney tubules partially lose their anti-ferroptotic capacity, similar to ovariectomized mice. While ESR1 promotes the anti-ferroptotic hydropersulfide system, male tubules express pro-ferroptotic proteins of the ether lipid pathway which are suppressed by ESR1 in female tissues until menopause. In summary, we identified non-genomic and genomic mechanisms that collectively explain ferroptosis resistance in female tubules and may function as therapeutic targets for male and postmenopausal female individuals.
000303496 536__ $$0G:(DE-HGF)POF4-311$$a311 - Zellbiologie und Tumorbiologie (POF4-311)$$cPOF4-311$$fPOF IV$$x0
000303496 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000303496 7001_ $$aMaremonti, Francesca$$b1
000303496 7001_ $$00000-0003-2876-1453$$aGavali, Shubhangi$$b2
000303496 7001_ $$00000-0001-8893-5326$$aSchlecht, Marlena Nastassja$$b3
000303496 7001_ $$aGembardt, Florian$$b4
000303496 7001_ $$00000-0001-6311-5858$$aBelavgeni, Alexia$$b5
000303496 7001_ $$aLeinung, Nadja$$b6
000303496 7001_ $$00009-0009-5449-2825$$aFlade, Karolin$$b7
000303496 7001_ $$aBethe, Natalie$$b8
000303496 7001_ $$aTraikov, Sofia$$b9
000303496 7001_ $$00009-0009-5111-7413$$aHaag, Anne$$b10
000303496 7001_ $$0P:(DE-He78)4e0aeb30e4b63dfe6d5b210b766e2c57$$aSchilling, Danny$$b11$$udkfz
000303496 7001_ $$aPenkov, Sider$$b12
000303496 7001_ $$aMallais, Melodie$$b13
000303496 7001_ $$00000-0002-1208-1130$$aGaillet, Christine$$b14
000303496 7001_ $$aMeyer, Claudia$$b15
000303496 7001_ $$aKatebi, Melika$$b16
000303496 7001_ $$aRay, Anushka$$b17
000303496 7001_ $$aGerhardt, Louisa M S$$b18
000303496 7001_ $$aBrucker, Anne$$b19
000303496 7001_ $$00009-0004-5273-1320$$aBecker, Jorunn Naila$$b20
000303496 7001_ $$00009-0002-4116-3634$$aTmava, Mirela$$b21
000303496 7001_ $$0P:(DE-He78)e52c8f6ae826320eaf2fb173e162070d$$aSchlicker, Lisa$$b22
000303496 7001_ $$0P:(DE-He78)94ae391f53fb9285e1b68f9930615af1$$aSchulze, Almut$$b23$$udkfz
000303496 7001_ $$00000-0002-2910-6728$$aHimmerkus, Nina$$b24
000303496 7001_ $$00000-0002-5079-1109$$aShevchenko, Andrej$$b25
000303496 7001_ $$aPeitzsch, Mirko$$b26
000303496 7001_ $$aBarayeu, Uladzimir$$b27
000303496 7001_ $$00000-0002-6625-8309$$aNasi, Sonia$$b28
000303496 7001_ $$aPutz, Juliane$$b29
000303496 7001_ $$00000-0002-7765-418X$$aKorach, Kenneth S$$b30
000303496 7001_ $$aNeugarten, Joel$$b31
000303496 7001_ $$aGolestaneh, Ladan$$b32
000303496 7001_ $$00000-0001-5895-3005$$aHugo, Christian$$b33
000303496 7001_ $$aBecker, Jan Ulrich$$b34
000303496 7001_ $$aWeinberg, Joel M$$b35
000303496 7001_ $$00000-0002-6856-0720$$aLorenz, Svenja$$b36
000303496 7001_ $$00000-0002-4119-9437$$aProneth, Bettina$$b37
000303496 7001_ $$aConrad, Marcus$$b38
000303496 7001_ $$00000-0002-0430-9510$$aWolf, Eckhard$$b39
000303496 7001_ $$00000-0001-8423-6173$$aPlietker, Bernd$$b40
000303496 7001_ $$00000-0001-7668-446X$$aRodriguez, Raphaël$$b41
000303496 7001_ $$00000-0002-7305-745X$$aPratt, Derek A$$b42
000303496 7001_ $$0P:(DE-He78)7f55a0ed8b021080de00960cc73768fb$$aDick, Tobias P$$b43$$udkfz
000303496 7001_ $$00000-0002-4692-3885$$aFedorova, Maria$$b44
000303496 7001_ $$aBornstein, Stefan R$$b45
000303496 7001_ $$00000-0001-6287-9725$$aLinkermann, Andreas$$b46
000303496 773__ $$0PERI:(DE-600)1413423-8$$a10.1038/s41586-025-09389-x$$pnn$$tNature$$vnn$$x0028-0836$$y2025
000303496 909CO $$ooai:inrepo02.dkfz.de:303496$$pVDB
000303496 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)4e0aeb30e4b63dfe6d5b210b766e2c57$$aDeutsches Krebsforschungszentrum$$b11$$kDKFZ
000303496 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)e52c8f6ae826320eaf2fb173e162070d$$aDeutsches Krebsforschungszentrum$$b22$$kDKFZ
000303496 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)94ae391f53fb9285e1b68f9930615af1$$aDeutsches Krebsforschungszentrum$$b23$$kDKFZ
000303496 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)7f55a0ed8b021080de00960cc73768fb$$aDeutsches Krebsforschungszentrum$$b43$$kDKFZ
000303496 9131_ $$0G:(DE-HGF)POF4-311$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vZellbiologie und Tumorbiologie$$x0
000303496 9141_ $$y2025
000303496 915__ $$0StatID:(DE-HGF)3003$$2StatID$$aDEAL Nature$$d2025-01-06$$wger
000303496 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2025-01-06
000303496 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2025-01-06
000303496 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2025-01-06
000303496 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2025-01-06
000303496 915__ $$0StatID:(DE-HGF)1060$$2StatID$$aDBCoverage$$bCurrent Contents - Agriculture, Biology and Environmental Sciences$$d2025-01-06
000303496 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences$$d2025-01-06
000303496 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2025-01-06
000303496 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2025-01-06
000303496 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2025-01-06
000303496 915__ $$0StatID:(DE-HGF)1200$$2StatID$$aDBCoverage$$bChemical Reactions$$d2025-01-06
000303496 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2025-01-06
000303496 915__ $$0StatID:(DE-HGF)1210$$2StatID$$aDBCoverage$$bIndex Chemicus$$d2025-01-06
000303496 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2025-01-06
000303496 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2025-01-06
000303496 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNATURE : 2022$$d2025-01-06
000303496 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2025-01-06
000303496 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2025-01-06
000303496 915__ $$0StatID:(DE-HGF)9960$$2StatID$$aIF >= 60$$bNATURE : 2022$$d2025-01-06
000303496 9201_ $$0I:(DE-He78)A160-20160331$$kA160$$lA160 Redoxregulation$$x0
000303496 9201_ $$0I:(DE-He78)A410-20160331$$kA410$$lMetabolismus und Microenvironment$$x1
000303496 980__ $$ajournal
000303496 980__ $$aVDB
000303496 980__ $$aI:(DE-He78)A160-20160331
000303496 980__ $$aI:(DE-He78)A410-20160331
000303496 980__ $$aUNRESTRICTED