Home > Publications database > Multiple oestradiol functions inhibit ferroptosis and acute kidney injury. > print

001     303496
005     20250817022126.0
024 7 _ |a 10.1038/s41586-025-09389-x
|2 doi
024 7 _ |a pmid:40804518
|2 pmid
024 7 _ |a 0028-0836
|2 ISSN
024 7 _ |a 1476-4687
|2 ISSN
024 7 _ |a altmetric:180267545
|2 altmetric
037 _ _ |a DKFZ-2025-01687
041 _ _ |a English
082 _ _ |a 500
100 1 _ |a Tonnus, Wulf
|0 0000-0002-9728-1413
|b 0
245 _ _ |a Multiple oestradiol functions inhibit ferroptosis and acute kidney injury.
260 _ _ |a London [u.a.]
|c 2025
|b Nature Publ. Group
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1755242046_8667
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
500 _ _ |a DKFZ-ZMBH Alliance / epub
520 _ _ |a Acute tubular necrosis mediates acute kidney injury (AKI) and nephron loss1, the hallmark of end-stage renal disease2-4. For decades, it has been known that female kidneys are less sensitive to AKI5,6. Acute tubular necrosis involves dynamic cell death propagation by ferroptosis along the tubular compartment7,8. Here we demonstrate abrogated ferroptotic cell death propagation in female kidney tubules. 17β-oestradiol establishes an anti-ferroptotic state through non-genomic and genomic mechanisms. These include the potent direct inhibition of ferroptosis by hydroxyoestradiol derivatives, which function as radical trapping antioxidants, are present at high concentrations in kidney tubules and, when exogenously applied, protect male mice from AKI. In cells, the oxidized hydroxyoestradiols are recycled by FSP19,10, but FSP1-deficient female mice were not sensitive to AKI. At the genomic level, female ESR1-deficient kidney tubules partially lose their anti-ferroptotic capacity, similar to ovariectomized mice. While ESR1 promotes the anti-ferroptotic hydropersulfide system, male tubules express pro-ferroptotic proteins of the ether lipid pathway which are suppressed by ESR1 in female tissues until menopause. In summary, we identified non-genomic and genomic mechanisms that collectively explain ferroptosis resistance in female tubules and may function as therapeutic targets for male and postmenopausal female individuals.
536 _ _ |a 311 - Zellbiologie und Tumorbiologie (POF4-311)
|0 G:(DE-HGF)POF4-311
|c POF4-311
|f POF IV
|x 0
588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
700 1 _ |a Maremonti, Francesca
|b 1
700 1 _ |a Gavali, Shubhangi
|0 0000-0003-2876-1453
|b 2
700 1 _ |a Schlecht, Marlena Nastassja
|0 0000-0001-8893-5326
|b 3
700 1 _ |a Gembardt, Florian
|b 4
700 1 _ |a Belavgeni, Alexia
|0 0000-0001-6311-5858
|b 5
700 1 _ |a Leinung, Nadja
|b 6
700 1 _ |a Flade, Karolin
|0 0009-0009-5449-2825
|b 7
700 1 _ |a Bethe, Natalie
|b 8
700 1 _ |a Traikov, Sofia
|b 9
700 1 _ |a Haag, Anne
|0 0009-0009-5111-7413
|b 10
700 1 _ |a Schilling, Danny
|0 P:(DE-He78)4e0aeb30e4b63dfe6d5b210b766e2c57
|b 11
|u dkfz
700 1 _ |a Penkov, Sider
|b 12
700 1 _ |a Mallais, Melodie
|b 13
700 1 _ |a Gaillet, Christine
|0 0000-0002-1208-1130
|b 14
700 1 _ |a Meyer, Claudia
|b 15
700 1 _ |a Katebi, Melika
|b 16
700 1 _ |a Ray, Anushka
|b 17
700 1 _ |a Gerhardt, Louisa M S
|b 18
700 1 _ |a Brucker, Anne
|b 19
700 1 _ |a Becker, Jorunn Naila
|0 0009-0004-5273-1320
|b 20
700 1 _ |a Tmava, Mirela
|0 0009-0002-4116-3634
|b 21
700 1 _ |a Schlicker, Lisa
|0 P:(DE-He78)e52c8f6ae826320eaf2fb173e162070d
|b 22
700 1 _ |a Schulze, Almut
|0 P:(DE-He78)94ae391f53fb9285e1b68f9930615af1
|b 23
|u dkfz
700 1 _ |a Himmerkus, Nina
|0 0000-0002-2910-6728
|b 24
700 1 _ |a Shevchenko, Andrej
|0 0000-0002-5079-1109
|b 25
700 1 _ |a Peitzsch, Mirko
|b 26
700 1 _ |a Barayeu, Uladzimir
|b 27
700 1 _ |a Nasi, Sonia
|0 0000-0002-6625-8309
|b 28
700 1 _ |a Putz, Juliane
|b 29
700 1 _ |a Korach, Kenneth S
|0 0000-0002-7765-418X
|b 30
700 1 _ |a Neugarten, Joel
|b 31
700 1 _ |a Golestaneh, Ladan
|b 32
700 1 _ |a Hugo, Christian
|0 0000-0001-5895-3005
|b 33
700 1 _ |a Becker, Jan Ulrich
|b 34
700 1 _ |a Weinberg, Joel M
|b 35
700 1 _ |a Lorenz, Svenja
|0 0000-0002-6856-0720
|b 36
700 1 _ |a Proneth, Bettina
|0 0000-0002-4119-9437
|b 37
700 1 _ |a Conrad, Marcus
|b 38
700 1 _ |a Wolf, Eckhard
|0 0000-0002-0430-9510
|b 39
700 1 _ |a Plietker, Bernd
|0 0000-0001-8423-6173
|b 40
700 1 _ |a Rodriguez, Raphaël
|0 0000-0001-7668-446X
|b 41
700 1 _ |a Pratt, Derek A
|0 0000-0002-7305-745X
|b 42
700 1 _ |a Dick, Tobias P
|0 P:(DE-He78)7f55a0ed8b021080de00960cc73768fb
|b 43
|u dkfz
700 1 _ |a Fedorova, Maria
|0 0000-0002-4692-3885
|b 44
700 1 _ |a Bornstein, Stefan R
|b 45
700 1 _ |a Linkermann, Andreas
|0 0000-0001-6287-9725
|b 46
773 _ _ |a 10.1038/s41586-025-09389-x
|0 PERI:(DE-600)1413423-8
|p nn
|t Nature
|v nn
|y 2025
|x 0028-0836
909 C O |o oai:inrepo02.dkfz.de:303496
|p VDB
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 11
|6 P:(DE-He78)4e0aeb30e4b63dfe6d5b210b766e2c57
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 22
|6 P:(DE-He78)e52c8f6ae826320eaf2fb173e162070d
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 23
|6 P:(DE-He78)94ae391f53fb9285e1b68f9930615af1
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 43
|6 P:(DE-He78)7f55a0ed8b021080de00960cc73768fb
913 1 _ |a DE-HGF
|b Gesundheit
|l Krebsforschung
|1 G:(DE-HGF)POF4-310
|0 G:(DE-HGF)POF4-311
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-300
|4 G:(DE-HGF)POF
|v Zellbiologie und Tumorbiologie
|x 0
914 1 _ |y 2025
915 _ _ |a DEAL Nature
|0 StatID:(DE-HGF)3003
|2 StatID
|d 2025-01-06
|w ger
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2025-01-06
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2025-01-06
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2025-01-06
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1040
|2 StatID
|b Zoological Record
|d 2025-01-06
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1060
|2 StatID
|b Current Contents - Agriculture, Biology and Environmental Sciences
|d 2025-01-06
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1150
|2 StatID
|b Current Contents - Physical, Chemical and Earth Sciences
|d 2025-01-06
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
|d 2025-01-06
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0160
|2 StatID
|b Essential Science Indicators
|d 2025-01-06
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1030
|2 StatID
|b Current Contents - Life Sciences
|d 2025-01-06
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1200
|2 StatID
|b Chemical Reactions
|d 2025-01-06
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1190
|2 StatID
|b Biological Abstracts
|d 2025-01-06
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1210
|2 StatID
|b Index Chemicus
|d 2025-01-06
915 _ _ |a WoS
|0 StatID:(DE-HGF)0113
|2 StatID
|b Science Citation Index Expanded
|d 2025-01-06
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2025-01-06
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b NATURE : 2022
|d 2025-01-06
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
|d 2025-01-06
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
|d 2025-01-06
915 _ _ |a IF >= 60
|0 StatID:(DE-HGF)9960
|2 StatID
|b NATURE : 2022
|d 2025-01-06
920 1 _ |0 I:(DE-He78)A160-20160331
|k A160
|l A160 Redoxregulation
|x 0
920 1 _ |0 I:(DE-He78)A410-20160331
|k A410
|l Metabolismus und Microenvironment
|x 1
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a I:(DE-He78)A160-20160331
980 _ _ |a I:(DE-He78)A410-20160331
980 _ _ |a UNRESTRICTED

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21