%0 Journal Article
%A Blumenfeld, Philip
%A Pryanichnikov, Alexander
%A Hillman, Yair
%A Wajnryt, Ella
%A Berger, Aviad
%A Winograd, Shimshon
%A Wygoda, Marc
%A Salhab, Ayman
%A Fang, Marcel
%A Feldman, Jon
%A Popovtzer, Aron
%T Prospective clinical trial of upright image-guided proton therapy for locally recurrent head and neck and brain malignancies.
%J Radiotherapy and oncology
%V 211
%@ 0167-8140
%C Amsterdam [u.a.]
%I Elsevier Science
%M DKFZ-2025-01690
%P 111097
%D 2025
%Z #EA:E041# / Volume 211, October 2025, 111097
%X The advent of commercially available vertical CT systems has renewed interest in gantry-less proton therapy (PT), in which patients are treated in an upright position using a fixed beamline and robotic positioning. This study evaluates the feasibility, safety, and preliminary efficacy of novel gantry-less image-guided adaptive PT (IGAPT) for recurrent head and neck (HN) and brain malignancies.A planned interim analysis was performed on 20 adult patients with recurrent HN (80 
%K Adaptive radiotherapy (Other)
%K Image guidance (Other)
%K Proton therapy (Other)
%K Radiotherapy (Other)
%K Upright CT (Other)
%K Upright treatments (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40803484
%R 10.1016/j.radonc.2025.111097
%U https://inrepo02.dkfz.de/record/303499