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@ARTICLE{Kraske:303509,
      author       = {J. Kraske$^*$ and M. M. Allers$^*$ and A. Smirnov$^*$ and
                      B. Lenoir$^*$ and A. Ahmed$^*$ and M. Suarez-Carmona$^*$ and
                      M. Hampel$^*$ and D. Krunic$^*$ and A. Tietz-Dalfuß$^*$ and
                      T. Beikert$^*$ and J. M. Schneeweiss$^*$ and S. Brons and D.
                      Albrecht$^*$ and T. Trinh$^*$ and M. Liu$^*$ and N.
                      Giese$^*$ and C. Glowa$^*$ and J. Liermann and R. Lopez
                      Perez$^*$ and D. Jäger$^*$ and J. Debus$^*$ and N.
                      Halama$^*$ and P. Huber$^*$ and T. Walle$^*$},
      title        = {{P}hoton and particle radiotherapy induce redundant modular
                      chemotaxis of human lymphocytes.},
      journal      = {JCI insight},
      volume       = {10},
      number       = {18},
      issn         = {2379-3708},
      address      = {Ann Arbor, Michigan},
      publisher    = {JCI Insight},
      reportid     = {DKFZ-2025-01699},
      pages        = {e190149},
      year         = {2025},
      note         = {#EA:E055#LA:E055# / 2025 Aug 14;10(18):e190149},
      abstract     = {Radiotherapy triggers chemokine release and leukocyte
                      infiltration in pre-clinical models through activation of
                      the senescence-associated secretory phenotype (SASP).
                      However, effects of irradiation on senescence and SASP in
                      human tissue and in the context of particle radiotherapy
                      remain unclear. Here, we analyzed chemokine patterns after
                      radiotherapy of human pancreatic tumors and cancer cell
                      lines. We show that irradiated tumor cells co-express SASP
                      chemokines in defined modules. These chemokine modules
                      correlated with infiltration of distinct leukocyte subtypes
                      expressing cognate receptors. We developed a patient-derived
                      pancreatic tumor explant system, which confirmed our
                      identified radiation-induced chemokine modules. Chemokine
                      modules were partially conserved in cancer cells in response
                      to photon and particle irradiation showing a dose-dependent
                      plateau effect and induced subsequent migration of NK and T
                      cell populations. Hence, our work reveals redundant
                      interactions of cancer cells and immune cells in human
                      tissue, suggesting that targeting multiple chemokines is
                      required to efficiently perturb leukocyte infiltration after
                      photon or particle radiotherapy.},
      keywords     = {Cellular senescence (Other) / Chemokines (Other) /
                      Immunology (Other) / Oncology (Other) / Radiation therapy
                      (Other)},
      cin          = {E055 / D120 / D196 / W210 / E040 / E050},
      ddc          = {610},
      cid          = {I:(DE-He78)E055-20160331 / I:(DE-He78)D120-20160331 /
                      I:(DE-He78)D196-20160331 / I:(DE-He78)W210-20160331 /
                      I:(DE-He78)E040-20160331 / I:(DE-He78)E050-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40811032},
      doi          = {10.1172/jci.insight.190149},
      url          = {https://inrepo02.dkfz.de/record/303509},
}