%0 Journal Article
%A Yuan, Tanwei
%A Tagscherer, Katrin E
%A Roth, Wilfried
%A Bewerunge-Hudler, Melanie
%A Brobeil, Alexander
%A Kloor, Matthias
%A Bläker, Hendrik
%A Brenner, Hermann
%A Hoffmeister, Michael
%T Methylation-based alcohol consumption scores as prognostic biomarkers in colorectal cancer: Insights from a population-based cohort.
%J International journal of cancer
%V 157
%N 12
%@ 0020-7136
%C Bognor Regis
%I Wiley-Liss
%M DKFZ-2025-01731
%P 2521-2531
%D 2025
%Z #EA:C070#LA:C070# / Volume 157, Issue 12 pp. 2521-2531
%X Colorectal cancer (CRC) remains a leading cause of cancer-related mortality, with alcohol consumption implicated in its etiology. However, alcohol's prognostic impact on CRC survival is unclear, and self-reported intake is limited by bias. This population-based cohort study evaluated blood DNA methylation-based alcohol scores as objective prognostic tools in 2,129 CRC patients from Germany's DACHS study (2003-2021; median follow-up: 10 years). Participants were recruited from 22 hospitals in Southwest Germany, including non-metastatic (n = 1757) and metastatic (n = 372) patients with complete methylation and alcohol data. All three assessed methylation scores (3-CpG, 450-CpG, 144-CpG) correlated with self-reported lifetime/recent alcohol intake (Spearman's r: 0.29-0.36; p < 0.0001), particularly recent consumption. In non-metastatic patients, self-reported alcohol consumption showed a J-shaped mortality risk, with elevated risks in heavy drinkers and abstainers. A similar dose-response pattern was observed for the 3-CpG methylation score, which showed consistent and robust associations with increased overall mortality (adjusted hazard ratio [aHR] per standard deviation increase: 1.18, 95
%K DNA methylation (Other)
%K alcohol consumption (Other)
%K colorectal cancer (Other)
%K population‐based cohort (Other)
%K prognosis (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40827617
%R 10.1002/ijc.70086
%U https://inrepo02.dkfz.de/record/303956