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@ARTICLE{Maura:303964,
      author       = {F. Maura and M. Kaddoura and A. Poos$^*$ and L. B. Baughn
                      and B. Ziccheddu and M.-A. Bärtsch$^*$ and A. Cirrincione
                      and K. Maclachlan and M. Chojnacka and B. Diamond and M.
                      Papadimitriou and P. Blaney and L. John$^*$ and P. Reichert
                      and S. Huhn and D. Gagler and Y. Zhang and A. Dogan and A.
                      M. Lesokhin and F. Davies and H. Goldschmidt and R. Fenk and
                      K. C. Weisel and E. K. Mai and N. Korde and G. J. Morgan and
                      S. V. Rajkumar and S. Kumar and S. Usmani and O. Landgren
                      and M.-S. Raab$^*$ and N. Weinhold$^*$},
      title        = {{T}emporal genomic dynamics shape clinical trajectory in
                      multiple myeloma.},
      journal      = {Nature genetics},
      volume       = {nn},
      issn         = {1061-4036},
      address      = {London},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DKFZ-2025-01733},
      pages        = {nn},
      year         = {2025},
      note         = {#EA:A360#LA:A360# / epub},
      abstract     = {Multiple myeloma evolution is characterized by the
                      accumulation of genomic drivers over time. To unravel this
                      timeline and its impact on clinical outcomes, we analyzed
                      421 whole-genome sequences from 382 patients. Using
                      clock-like mutational signatures, we estimated a time lag of
                      two to four decades between the initiation of events and
                      diagnosis. We demonstrate that odd-numbered chromosome
                      trisomies in patients with hyperdiploidy can be acquired
                      simultaneously with other chromosomal gains (for example, 1q
                      gain). We show that hyperdiploidy is acquired after
                      immunoglobulin heavy chain translocation when both events
                      co-occur. Finally, patients with early 1q gain had adverse
                      outcomes similar to those with 1q amplification (>1 extra
                      copy), but fared worse than those with late 1q gain. This
                      finding underscores that the 1q gain prognostic impact
                      depends more on the timing of acquisition than on the number
                      of copies gained. Overall, this study contributes to a
                      better understanding of the life history of myeloma and may
                      have prognostic implications.},
      cin          = {A360},
      ddc          = {570},
      cid          = {I:(DE-He78)A360-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40835892},
      doi          = {10.1038/s41588-025-02292-1},
      url          = {https://inrepo02.dkfz.de/record/303964},
}