TY  - JOUR
AU  - Lange, Sebastian
AU  - Lisiecki, Hannah
AU  - Kreutzfeldt, Simon
AU  - Heining, Christoph
AU  - Weiss, Lena
AU  - Westphalen, Christoph Benedikt
AU  - Stenzinger, Albrecht
AU  - Hübschmann, Daniel
AU  - Jesinghaus, Moritz
AU  - Glimm, Hanno
AU  - Fröhling, Stefan
AU  - Pfarr, Nicole
AU  - Schlitter, Anna Melissa
TI  - Precision oncology for advanced-stage adenocarcinoma of the appendix: comprehensive molecular characterisation identifies actionable lesions and potential predictive biomarkers.
JO  - BMJ open gastroenterology
VL  - 12
IS  - 1
SN  - 2054-4774
CY  - London
PB  - BMJ Publishing Group
M1  - DKFZ-2025-01745
SP  - e001671
PY  - 2025
AB  - Appendiceal adenocarcinoma is a rare cancer with very limited therapeutic options. We aimed to determine whether molecular profiling of advanced appendiceal adenocancer can identify actionable therapeutic alterations.We retrospectively analysed cohorts from two large German precision oncology programmes. Patient records and pathology reports from 19 patients with advanced appendiceal adenocarcinoma who were enrolled between 2015 and 2021 were included in this study. We report the molecular features, the resulting molecular tumour board recommendations and their clinical implementation.In 95
KW  - Humans
KW  - Appendiceal Neoplasms: genetics
KW  - Appendiceal Neoplasms: pathology
KW  - Appendiceal Neoplasms: therapy
KW  - Female
KW  - Male
KW  - Adenocarcinoma: genetics
KW  - Adenocarcinoma: pathology
KW  - Adenocarcinoma: therapy
KW  - Adenocarcinoma: drug therapy
KW  - Retrospective Studies
KW  - Middle Aged
KW  - Precision Medicine: methods
KW  - Aged
KW  - Biomarkers, Tumor: genetics
KW  - Mutation
KW  - Class I Phosphatidylinositol 3-Kinases: genetics
KW  - Adult
KW  - Neoplasm Staging
KW  - Aged, 80 and over
KW  - Ataxia Telangiectasia Mutated Proteins: genetics
KW  - Proto-Oncogene Proteins c-akt: genetics
KW  - Germany
KW  - CANCER (Other)
KW  - COLORECTAL NEOPLASIA (Other)
KW  - MOLECULAR PATHOLOGY (Other)
KW  - Biomarkers, Tumor (NLM Chemicals)
KW  - Class I Phosphatidylinositol 3-Kinases (NLM Chemicals)
KW  - PIK3CA protein, human (NLM Chemicals)
KW  - Ataxia Telangiectasia Mutated Proteins (NLM Chemicals)
KW  - ATM protein, human (NLM Chemicals)
KW  - Proto-Oncogene Proteins c-akt (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40840958
DO  - DOI:10.1136/bmjgast-2024-001671
UR  - https://inrepo02.dkfz.de/record/303976
ER  -