%0 Journal Article
%A Shugaa Addin, Nuha
%A Schuppert, Christopher
%A Full, Peter
%A Brenner, Hermann
%A Dörr, Marcus
%A Keil, Thomas
%A von Krüchten, Ricarda
%A Meinel, Felix G
%A Niendorf, Thoralf
%A Pischon, Tobias
%A Schmidt, Börge
%A Schulz-Menger, Jeanette
%A Schwichtenberg, Julia
%A Völzke, Henry
%A Willich, Stefan N
%A Bamberg, Fabian
%A Peters, Annette
%A Schlett, Christopher L
%A Rospleszcz, Susanne
%T Magnesium Depletion, Metabolic Impairment, and Cardiac Alterations: The NAKO-MRI Study with Mendelian Randomization.
%J The journal of clinical endocrinology & metabolism
%V nn
%@ 0368-1610
%C Oxford
%I Oxford University Press
%M DKFZ-2025-01747
%P nn
%D 2025
%Z epub
%X Magnesium deficiency may contribute to subclinical cardiac changes, particularly metabolic diastolic cardiomyopathy.To investigate the association between magnesium depletion, metabolic syndrome (MetS), and MRI-derived cardiac alterations in a population-based sample.We cross-sectionally analyzed N = 9568 participants from the baseline examination of the German National Cohort (NAKO) who underwent whole-body MRI. Associations of serum magnesium and magnesium depletion score (MDS) with MetS and cardiac alterations were assessed using multivariable logistic and linear regression, respectively. Two-sample Mendelian Randomization was performed to evaluate the potential causal relationship between serum magnesium and MRI-derived cardiac parameters.Our analysis revealed no correlation between serum magnesium and MDS (Spearman's rho = 0.065; p < 0.001). A 1-SD increase in serum magnesium was associated with lower MetS prevalence (OR 0.93 [95
%K Magnesium (Other)
%K cardiac function (Other)
%K cardiac morphology (Other)
%K magnetic resonance imaging (Other)
%K metabolic syndrome (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40839755
%R 10.1210/clinem/dgaf476
%U https://inrepo02.dkfz.de/record/303978