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000303978 1001_ $$00000-0002-1499-9885$$aShugaa Addin, Nuha$$b0
000303978 245__ $$aMagnesium Depletion, Metabolic Impairment, and Cardiac Alterations: The NAKO-MRI Study with Mendelian Randomization.
000303978 260__ $$aOxford$$bOxford University Press$$c2025
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000303978 520__ $$aMagnesium deficiency may contribute to subclinical cardiac changes, particularly metabolic diastolic cardiomyopathy.To investigate the association between magnesium depletion, metabolic syndrome (MetS), and MRI-derived cardiac alterations in a population-based sample.We cross-sectionally analyzed N = 9568 participants from the baseline examination of the German National Cohort (NAKO) who underwent whole-body MRI. Associations of serum magnesium and magnesium depletion score (MDS) with MetS and cardiac alterations were assessed using multivariable logistic and linear regression, respectively. Two-sample Mendelian Randomization was performed to evaluate the potential causal relationship between serum magnesium and MRI-derived cardiac parameters.Our analysis revealed no correlation between serum magnesium and MDS (Spearman's rho = 0.065; p < 0.001). A 1-SD increase in serum magnesium was associated with lower MetS prevalence (OR 0.93 [95% CI: 0.88, 0.99]) and reduced left and right ventricular systolic and diastolic volumes. Higher MDS, indicating magnesium deficiency, was linked to increased MetS prevalence (OR per 1-unit 1.32 [95% CI: 1.23, 1.41]) and its individual components. Furthermore, higher MDS was associated with increased LVRI (Estimate 0.012 g/mL [95% CI: 0.008, 0.017]) and decreased left ventricular end-diastolic volume (Estimate -1.132 mL/m2 [95% CI: -1.538, -0.727]), indicating concentric hypertrophy. Two-sample Mendelian Randomization suggested no causal relationship between serum magnesium and MRI-derived cardiac markers.Magnesium depletion may serve as an early indicator of cardiac impairment. However, Mendelian Randomization results do not support a causal role of serum magnesium on cardiac structure and morphology.
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000303978 650_7 $$2Other$$aMagnesium
000303978 650_7 $$2Other$$acardiac function
000303978 650_7 $$2Other$$acardiac morphology
000303978 650_7 $$2Other$$amagnetic resonance imaging
000303978 650_7 $$2Other$$ametabolic syndrome
000303978 7001_ $$00000-0002-9675-803X$$aSchuppert, Christopher$$b1
000303978 7001_ $$0P:(DE-He78)e9dc924f238fa6cc29465942875fe8f0$$aFull, Peter$$b2
000303978 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b3$$udkfz
000303978 7001_ $$aDörr, Marcus$$b4
000303978 7001_ $$aKeil, Thomas$$b5
000303978 7001_ $$avon Krüchten, Ricarda$$b6
000303978 7001_ $$aMeinel, Felix G$$b7
000303978 7001_ $$00000-0001-7584-6527$$aNiendorf, Thoralf$$b8
000303978 7001_ $$aPischon, Tobias$$b9
000303978 7001_ $$aSchmidt, Börge$$b10
000303978 7001_ $$00000-0003-3100-1092$$aSchulz-Menger, Jeanette$$b11
000303978 7001_ $$aSchwichtenberg, Julia$$b12
000303978 7001_ $$00000-0001-7003-399X$$aVölzke, Henry$$b13
000303978 7001_ $$aWillich, Stefan N$$b14
000303978 7001_ $$00000-0002-7460-3942$$aBamberg, Fabian$$b15
000303978 7001_ $$aPeters, Annette$$b16
000303978 7001_ $$00000-0002-1576-1481$$aSchlett, Christopher L$$b17
000303978 7001_ $$00000-0002-4788-2341$$aRospleszcz, Susanne$$b18
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