TY  - JOUR
AU  - Shugaa Addin, Nuha
AU  - Schuppert, Christopher
AU  - Full, Peter
AU  - Brenner, Hermann
AU  - Dörr, Marcus
AU  - Keil, Thomas
AU  - von Krüchten, Ricarda
AU  - Meinel, Felix G
AU  - Niendorf, Thoralf
AU  - Pischon, Tobias
AU  - Schmidt, Börge
AU  - Schulz-Menger, Jeanette
AU  - Schwichtenberg, Julia
AU  - Völzke, Henry
AU  - Willich, Stefan N
AU  - Bamberg, Fabian
AU  - Peters, Annette
AU  - Schlett, Christopher L
AU  - Rospleszcz, Susanne
TI  - Magnesium Depletion, Metabolic Impairment, and Cardiac Alterations: The NAKO-MRI Study with Mendelian Randomization.
JO  - The journal of clinical endocrinology & metabolism
VL  - nn
SN  - 0368-1610
CY  - Oxford
PB  - Oxford University Press
M1  - DKFZ-2025-01747
SP  - nn
PY  - 2025
N1  - epub
AB  - Magnesium deficiency may contribute to subclinical cardiac changes, particularly metabolic diastolic cardiomyopathy.To investigate the association between magnesium depletion, metabolic syndrome (MetS), and MRI-derived cardiac alterations in a population-based sample.We cross-sectionally analyzed N = 9568 participants from the baseline examination of the German National Cohort (NAKO) who underwent whole-body MRI. Associations of serum magnesium and magnesium depletion score (MDS) with MetS and cardiac alterations were assessed using multivariable logistic and linear regression, respectively. Two-sample Mendelian Randomization was performed to evaluate the potential causal relationship between serum magnesium and MRI-derived cardiac parameters.Our analysis revealed no correlation between serum magnesium and MDS (Spearman's rho = 0.065; p < 0.001). A 1-SD increase in serum magnesium was associated with lower MetS prevalence (OR 0.93 [95
KW  - Magnesium (Other)
KW  - cardiac function (Other)
KW  - cardiac morphology (Other)
KW  - magnetic resonance imaging (Other)
KW  - metabolic syndrome (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40839755
DO  - DOI:10.1210/clinem/dgaf476
UR  - https://inrepo02.dkfz.de/record/303978
ER  -