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@ARTICLE{ShugaaAddin:303978,
      author       = {N. Shugaa Addin and C. Schuppert and P. Full$^*$ and H.
                      Brenner$^*$ and M. Dörr and T. Keil and R. von Krüchten
                      and F. G. Meinel and T. Niendorf and T. Pischon and B.
                      Schmidt and J. Schulz-Menger and J. Schwichtenberg and H.
                      Völzke and S. N. Willich and F. Bamberg and A. Peters and
                      C. L. Schlett and S. Rospleszcz},
      title        = {{M}agnesium {D}epletion, {M}etabolic {I}mpairment, and
                      {C}ardiac {A}lterations: {T}he {NAKO}-{MRI} {S}tudy with
                      {M}endelian {R}andomization.},
      journal      = {The journal of clinical endocrinology $\&$ metabolism},
      volume       = {nn},
      issn         = {0368-1610},
      address      = {Oxford},
      publisher    = {Oxford University Press},
      reportid     = {DKFZ-2025-01747},
      pages        = {nn},
      year         = {2025},
      note         = {epub},
      abstract     = {Magnesium deficiency may contribute to subclinical cardiac
                      changes, particularly metabolic diastolic cardiomyopathy.To
                      investigate the association between magnesium depletion,
                      metabolic syndrome (MetS), and MRI-derived cardiac
                      alterations in a population-based sample.We
                      cross-sectionally analyzed N = 9568 participants from the
                      baseline examination of the German National Cohort (NAKO)
                      who underwent whole-body MRI. Associations of serum
                      magnesium and magnesium depletion score (MDS) with MetS and
                      cardiac alterations were assessed using multivariable
                      logistic and linear regression, respectively. Two-sample
                      Mendelian Randomization was performed to evaluate the
                      potential causal relationship between serum magnesium and
                      MRI-derived cardiac parameters.Our analysis revealed no
                      correlation between serum magnesium and MDS (Spearman's rho
                      = 0.065; p < 0.001). A 1-SD increase in serum magnesium was
                      associated with lower MetS prevalence (OR 0.93 $[95\%$ CI:
                      0.88, 0.99]) and reduced left and right ventricular systolic
                      and diastolic volumes. Higher MDS, indicating magnesium
                      deficiency, was linked to increased MetS prevalence (OR per
                      1-unit 1.32 $[95\%$ CI: 1.23, 1.41]) and its individual
                      components. Furthermore, higher MDS was associated with
                      increased LVRI (Estimate 0.012 g/mL $[95\%$ CI: 0.008,
                      0.017]) and decreased left ventricular end-diastolic volume
                      (Estimate -1.132 mL/m2 $[95\%$ CI: -1.538, -0.727]),
                      indicating concentric hypertrophy. Two-sample Mendelian
                      Randomization suggested no causal relationship between serum
                      magnesium and MRI-derived cardiac markers.Magnesium
                      depletion may serve as an early indicator of cardiac
                      impairment. However, Mendelian Randomization results do not
                      support a causal role of serum magnesium on cardiac
                      structure and morphology.},
      keywords     = {Magnesium (Other) / cardiac function (Other) / cardiac
                      morphology (Other) / magnetic resonance imaging (Other) /
                      metabolic syndrome (Other)},
      cin          = {E230 / C070},
      ddc          = {610},
      cid          = {I:(DE-He78)E230-20160331 / I:(DE-He78)C070-20160331},
      pnm          = {319H - Addenda (POF4-319H)},
      pid          = {G:(DE-HGF)POF4-319H},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40839755},
      doi          = {10.1210/clinem/dgaf476},
      url          = {https://inrepo02.dkfz.de/record/303978},
}