guest ::
| Home > Publications database > Magnesium Depletion, Metabolic Impairment, and Cardiac Alterations: The NAKO-MRI Study with Mendelian Randomization. > print |
| Home > Publications database > Magnesium Depletion, Metabolic Impairment, and Cardiac Alterations: The NAKO-MRI Study with Mendelian Randomization. > print |
| 001 | 303978 | ||
| 005 | 20251203111636.0 | ||
| 024 | 7 | _ | |a 10.1210/clinem/dgaf476 |2 doi |
| 024 | 7 | _ | |a pmid:40839755 |2 pmid |
| 024 | 7 | _ | |a 0368-1610 |2 ISSN |
| 024 | 7 | _ | |a 0021-972X |2 ISSN |
| 024 | 7 | _ | |a 1945-7197 |2 ISSN |
| 037 | _ | _ | |a DKFZ-2025-01747 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Shugaa Addin, Nuha |0 0000-0002-1499-9885 |b 0 |
| 245 | _ | _ | |a Magnesium Depletion, Metabolic Impairment, and Cardiac Alterations: The NAKO-MRI Study with Mendelian Randomization. |
| 260 | _ | _ | |a Oxford |c 2025 |b Oxford University Press |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1764756975_1331672 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a epub |
| 520 | _ | _ | |a Magnesium deficiency may contribute to subclinical cardiac changes, particularly metabolic diastolic cardiomyopathy.To investigate the association between magnesium depletion, metabolic syndrome (MetS), and MRI-derived cardiac alterations in a population-based sample.We cross-sectionally analyzed N = 9568 participants from the baseline examination of the German National Cohort (NAKO) who underwent whole-body MRI. Associations of serum magnesium and magnesium depletion score (MDS) with MetS and cardiac alterations were assessed using multivariable logistic and linear regression, respectively. Two-sample Mendelian Randomization was performed to evaluate the potential causal relationship between serum magnesium and MRI-derived cardiac parameters.Our analysis revealed no correlation between serum magnesium and MDS (Spearman's rho = 0.065; p < 0.001). A 1-SD increase in serum magnesium was associated with lower MetS prevalence (OR 0.93 [95% CI: 0.88, 0.99]) and reduced left and right ventricular systolic and diastolic volumes. Higher MDS, indicating magnesium deficiency, was linked to increased MetS prevalence (OR per 1-unit 1.32 [95% CI: 1.23, 1.41]) and its individual components. Furthermore, higher MDS was associated with increased LVRI (Estimate 0.012 g/mL [95% CI: 0.008, 0.017]) and decreased left ventricular end-diastolic volume (Estimate -1.132 mL/m2 [95% CI: -1.538, -0.727]), indicating concentric hypertrophy. Two-sample Mendelian Randomization suggested no causal relationship between serum magnesium and MRI-derived cardiac markers.Magnesium depletion may serve as an early indicator of cardiac impairment. However, Mendelian Randomization results do not support a causal role of serum magnesium on cardiac structure and morphology. |
| 536 | _ | _ | |a 313 - Krebsrisikofaktoren und Prävention (POF4-313) |0 G:(DE-HGF)POF4-313 |c POF4-313 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de |
| 650 | _ | 7 | |a Magnesium |2 Other |
| 650 | _ | 7 | |a cardiac function |2 Other |
| 650 | _ | 7 | |a cardiac morphology |2 Other |
| 650 | _ | 7 | |a magnetic resonance imaging |2 Other |
| 650 | _ | 7 | |a metabolic syndrome |2 Other |
| 700 | 1 | _ | |a Schuppert, Christopher |0 0000-0002-9675-803X |b 1 |
| 700 | 1 | _ | |a Full, Peter |0 P:(DE-He78)e9dc924f238fa6cc29465942875fe8f0 |b 2 |
| 700 | 1 | _ | |a Brenner, Hermann |0 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2 |b 3 |u dkfz |
| 700 | 1 | _ | |a Dörr, Marcus |b 4 |
| 700 | 1 | _ | |a Keil, Thomas |b 5 |
| 700 | 1 | _ | |a von Krüchten, Ricarda |b 6 |
| 700 | 1 | _ | |a Meinel, Felix G |b 7 |
| 700 | 1 | _ | |a Niendorf, Thoralf |0 0000-0001-7584-6527 |b 8 |
| 700 | 1 | _ | |a Pischon, Tobias |b 9 |
| 700 | 1 | _ | |a Schmidt, Börge |b 10 |
| 700 | 1 | _ | |a Schulz-Menger, Jeanette |0 0000-0003-3100-1092 |b 11 |
| 700 | 1 | _ | |a Schwichtenberg, Julia |b 12 |
| 700 | 1 | _ | |a Völzke, Henry |0 0000-0001-7003-399X |b 13 |
| 700 | 1 | _ | |a Willich, Stefan N |b 14 |
| 700 | 1 | _ | |a Bamberg, Fabian |0 0000-0002-7460-3942 |b 15 |
| 700 | 1 | _ | |a Peters, Annette |b 16 |
| 700 | 1 | _ | |a Schlett, Christopher L |0 0000-0002-1576-1481 |b 17 |
| 700 | 1 | _ | |a Rospleszcz, Susanne |0 0000-0002-4788-2341 |b 18 |
| 773 | _ | _ | |a 10.1210/clinem/dgaf476 |g p. dgaf476 |0 PERI:(DE-600)2026217-6 |p nn |t The journal of clinical endocrinology & metabolism |v nn |y 2025 |x 0368-1610 |
| 909 | C | O | |p VDB |o oai:inrepo02.dkfz.de:303978 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 2 |6 P:(DE-He78)e9dc924f238fa6cc29465942875fe8f0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 3 |6 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Krebsforschung |1 G:(DE-HGF)POF4-310 |0 G:(DE-HGF)POF4-313 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Krebsrisikofaktoren und Prävention |x 0 |
| 914 | 1 | _ | |y 2025 |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |d 2024-12-30 |w ger |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b J CLIN ENDOCR METAB : 2022 |d 2024-12-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2024-12-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2024-12-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2024-12-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2024-12-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2024-12-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2024-12-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1190 |2 StatID |b Biological Abstracts |d 2024-12-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1110 |2 StatID |b Current Contents - Clinical Medicine |d 2024-12-30 |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2024-12-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2024-12-30 |
| 915 | _ | _ | |a IF >= 5 |0 StatID:(DE-HGF)9905 |2 StatID |b J CLIN ENDOCR METAB : 2022 |d 2024-12-30 |
| 920 | 1 | _ | |0 I:(DE-He78)E230-20160331 |k E230 |l E230 Medizinische Bildverarbeitung |x 0 |
| 920 | 1 | _ | |0 I:(DE-He78)C070-20160331 |k C070 |l C070 Klinische Epidemiologie der Krebsfrüherkennung |x 1 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)E230-20160331 |
| 980 | _ | _ | |a I:(DE-He78)C070-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|