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@ARTICLE{Haas:304085,
      author       = {A. Haas and F. Wenz and J. Hattemer and J. Wesslowski and
                      G. Davidson and O. Voloshanenko$^*$ and M. Boutros$^*$ and
                      S. P. Acebron and H. Bastians},
      title        = {{W}nt10b signaling regulates replication stress-induced
                      chromosomal instability in human cancer.},
      journal      = {Life science alliance},
      volume       = {8},
      number       = {11},
      issn         = {2575-1077},
      address      = {Heidelberg},
      publisher    = {EMBO Press},
      reportid     = {DKFZ-2025-01753},
      pages        = {e202503295},
      year         = {2025},
      abstract     = {Wnt signaling pathways are involved in various
                      developmental and tissue maintenance functions, whereas
                      deregulated Wnt signaling is closely linked to human cancer.
                      Recent work revealed that loss of Wnt signaling impairs
                      mitosis and causes abnormal microtubule growth at the
                      mitotic spindle resulting in chromosome missegregation and
                      aneuploidy, both of which are hallmarks of cancer cells
                      exhibiting chromosomal instability (CIN). Here, we show that
                      upon DNA replication stress, a condition typically
                      associated with CIN, Wnt10b acts to prevent increased
                      microtubule dynamics from the S phase until mitosis, thereby
                      ensuring faithful chromosome segregation. Interestingly,
                      replication stress-induced chromosomal breaks are also
                      efficiently suppressed by Wnt10b. Thus, our results show
                      that Wnt10b signaling regulates replication stress-induced
                      chromosome missegregation and breakage, and hence is a
                      determinant for broad genome instability in cancer cells.},
      keywords     = {Humans / Chromosomal Instability: genetics / DNA
                      Replication: genetics / Neoplasms: genetics / Neoplasms:
                      metabolism / Wnt Proteins: metabolism / Wnt Proteins:
                      genetics / Mitosis: genetics / Cell Line, Tumor / Chromosome
                      Segregation: genetics / Wnt Signaling Pathway: genetics /
                      Microtubules: metabolism / Genomic Instability / Signal
                      Transduction / Proto-Oncogene Proteins / Wnt Proteins (NLM
                      Chemicals) / WNT10B protein, human (NLM Chemicals) /
                      Proto-Oncogene Proteins (NLM Chemicals)},
      cin          = {B110},
      ddc          = {570},
      cid          = {I:(DE-He78)B110-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40846632},
      doi          = {10.26508/lsa.202503295},
      url          = {https://inrepo02.dkfz.de/record/304085},
}