Home > Publications database > Wnt10b signaling regulates replication stress-induced chromosomal instability in human cancer. > print

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082 _ _ |a 570
100 1 _ |a Haas, Alexander
|b 0
245 _ _ |a Wnt10b signaling regulates replication stress-induced chromosomal instability in human cancer.
260 _ _ |a Heidelberg
|c 2025
|b EMBO Press
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520 _ _ |a Wnt signaling pathways are involved in various developmental and tissue maintenance functions, whereas deregulated Wnt signaling is closely linked to human cancer. Recent work revealed that loss of Wnt signaling impairs mitosis and causes abnormal microtubule growth at the mitotic spindle resulting in chromosome missegregation and aneuploidy, both of which are hallmarks of cancer cells exhibiting chromosomal instability (CIN). Here, we show that upon DNA replication stress, a condition typically associated with CIN, Wnt10b acts to prevent increased microtubule dynamics from the S phase until mitosis, thereby ensuring faithful chromosome segregation. Interestingly, replication stress-induced chromosomal breaks are also efficiently suppressed by Wnt10b. Thus, our results show that Wnt10b signaling regulates replication stress-induced chromosome missegregation and breakage, and hence is a determinant for broad genome instability in cancer cells.
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650 _ 7 |a Wnt Proteins
|2 NLM Chemicals
650 _ 7 |a WNT10B protein, human
|2 NLM Chemicals
650 _ 7 |a Proto-Oncogene Proteins
|2 NLM Chemicals
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Chromosomal Instability: genetics
|2 MeSH
650 _ 2 |a DNA Replication: genetics
|2 MeSH
650 _ 2 |a Neoplasms: genetics
|2 MeSH
650 _ 2 |a Neoplasms: metabolism
|2 MeSH
650 _ 2 |a Wnt Proteins: metabolism
|2 MeSH
650 _ 2 |a Wnt Proteins: genetics
|2 MeSH
650 _ 2 |a Mitosis: genetics
|2 MeSH
650 _ 2 |a Cell Line, Tumor
|2 MeSH
650 _ 2 |a Chromosome Segregation: genetics
|2 MeSH
650 _ 2 |a Wnt Signaling Pathway: genetics
|2 MeSH
650 _ 2 |a Microtubules: metabolism
|2 MeSH
650 _ 2 |a Genomic Instability
|2 MeSH
650 _ 2 |a Signal Transduction
|2 MeSH
650 _ 2 |a Proto-Oncogene Proteins
|2 MeSH
700 1 _ |a Wenz, Friederike
|0 0009-0003-0114-2772
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700 1 _ |a Hattemer, Janina
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700 1 _ |a Wesslowski, Janine
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700 1 _ |a Davidson, Gary
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700 1 _ |a Voloshanenko, Oksana
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700 1 _ |a Boutros, Michael
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700 1 _ |a Acebron, Sergio P
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700 1 _ |a Bastians, Holger
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773 _ _ |a 10.26508/lsa.202503295
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