TY  - JOUR
AU  - Córdova, Reynalda
AU  - Kim, Jihye
AU  - Thompson, Alysha S
AU  - Noh, Hwayoung
AU  - Shah, Sanam
AU  - Dahm, Christina C
AU  - Jensen, Christopher F
AU  - Mellemkjær, Lene
AU  - Tjønneland, Anne
AU  - Katzke, Verena
AU  - Le Cornet, Charlotte
AU  - El-Khoury, Christine
AU  - Schulze, Matthias B
AU  - Masala, Giovanna
AU  - Agnoli, Claudia
AU  - Simeon, Vittorio
AU  - Tumino, Rosario
AU  - Ricceri, Fulvio
AU  - Verschuren, W M Monique
AU  - van der Schouw, Yvonne T
AU  - Castro-Espin, Carlota
AU  - Sánchez, Maria-José
AU  - Aizpurua, Amaia
AU  - Rodríguez Palacios, Daniel
AU  - Guevara, Marcela
AU  - Papier, Keren
AU  - Tong, Tammy Y N
AU  - Huybrechts, Inge
AU  - Wagner, Karl-Heinz
AU  - Matta, Komodo
AU  - Papadimitriou, Nikos
AU  - Heath, Alicia
AU  - Aune, Dagfinn
AU  - Gunter, Marc J
AU  - Ferrari, Pietro
AU  - Kühn, Tilman
AU  - Freisling, Heinz
TI  - Plant-based dietary patterns and age-specific risk of multimorbidity of cancer and cardiometabolic diseases: a prospective analysis.
JO  - The lancet / Healthy longevity
VL  - nn
SN  - 2666-7568
CY  - London
PB  - Elsevier
M1  - DKFZ-2025-01755
SP  - nn
PY  - 2025
N1  - epub
AB  - It is currently unknown whether plant-based dietary patterns influence disease progression to multimorbidity after an initial non-communicable disease, and whether the associated risk of multimorbidity varies with age. This study aimed to investigate associations of plant-based diets with the risk of multimorbidity, defined as the co-occurrence of at least two chronic diseases in an individual (either cancer at any site, cardiovascular disease, or type 2 diabetes).This prospective cohort study used data from EPIC and UK Biobank across six European countries, with participants aged 35-70 years at recruitment. We excluded participants from these cohorts who had cancer, cardiovascular disease, or type 2 diabetes at baseline or those with missing data on diet or health outcomes. Data on dietary habits were assessed either at baseline through a validated dietary questionnaire about habits in the previous 12 months or through several 24-h recall questionnaires during approximately a year of follow-up. Multistate modelling with Cox regression was used to estimate the risk of multimorbidity according to a healthful plant-based diet index (hPDI) and, separately, an unhealthful plant-based diet index (uPDI). Risk differences in adults younger than 60 years and those age 60 years and older were estimated.407 618 participants (226 324 from EPIC and 181 294 from UK Biobank) were included in this study. During a median follow-up time of 10·9 years in EPIC and 11·4 years in UK Biobank, 6604 cancer-cardiometabolic multimorbidity events occurred in both cohorts combined. A ten-point increment of the hPDI score was associated with a lower risk of multimorbidity, with a hazard ratio (HR) of 0·89 (95
LB  - PUB:(DE-HGF)16
C6  - pmid:40845891
DO  - DOI:10.1016/j.lanhl.2025.100742
UR  - https://inrepo02.dkfz.de/record/304087
ER  -