%0 Journal Article
%A Smith-Byrne, K.
%A Fensom, Georgina K
%A Noor, Urwah
%A Watts, Eleanor L
%A Allen, Naomi E
%A Amiano, Pilar
%A Chirlaque, María Dolores
%A Crous-Bou, Marta
%A Guevara Eslava, Marcela
%A Palli, Domenico
%A Katzke, Verena
%A Sacerdote, Carlotta
%A Sánchez, Maria-Jose
%A Schulze, Matthias B
%A Sieri, Sabina
%A Tumino, Rosario
%A Tsilidis, Konstantinos K
%A Kaaks, Rudolf
%A Gunter, Marc J
%A Riboli, Elio
%A Key, Timothy J
%A Travis, Ruth C
%T Evaluation of the 4Kscore test in relation to subsequent risk of aggressive prostate cancer in the European Prospective Investigation into Cancer and Nutrition.
%J Cancer epidemiology, biomarkers & prevention
%V nn
%@ 1055-9965
%C Philadelphia, Pa.
%I AACR
%M DKFZ-2025-01758
%P nn
%D 2025
%Z epub
%X Prostate-specific antigen (PSA) is central to referrals for prostate biopsy but has low specificity for aggressive prostate cancer. This study evaluates the 4Kscore® (OPKO Diagnostics) versus total PSA in predicting short- and long-term risks of aggressive prostate cancer.Baseline blood samples from 1,658 men diagnosed with prostate cancer (median diagnosis time = 8.6 years) and 1,658 matched controls in the European Prospective Investigation into Cancer and Nutrition (EPIC) were analyzed. Discrimination for the 4Kscore and total PSA was assessed using the area under the curve (AUC) with 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40844611
%R 10.1158/1055-9965.EPI-24-1877
%U https://inrepo02.dkfz.de/record/304090