TY  - JOUR
AU  - Smith-Byrne, K.
AU  - Fensom, Georgina K
AU  - Noor, Urwah
AU  - Watts, Eleanor L
AU  - Allen, Naomi E
AU  - Amiano, Pilar
AU  - Chirlaque, María Dolores
AU  - Crous-Bou, Marta
AU  - Guevara Eslava, Marcela
AU  - Palli, Domenico
AU  - Katzke, Verena
AU  - Sacerdote, Carlotta
AU  - Sánchez, Maria-Jose
AU  - Schulze, Matthias B
AU  - Sieri, Sabina
AU  - Tumino, Rosario
AU  - Tsilidis, Konstantinos K
AU  - Kaaks, Rudolf
AU  - Gunter, Marc J
AU  - Riboli, Elio
AU  - Key, Timothy J
AU  - Travis, Ruth C
TI  - Evaluation of the 4Kscore test in relation to subsequent risk of aggressive prostate cancer in the European Prospective Investigation into Cancer and Nutrition.
JO  - Cancer epidemiology, biomarkers & prevention
VL  - nn
SN  - 1055-9965
CY  - Philadelphia, Pa.
PB  - AACR
M1  - DKFZ-2025-01758
SP  - nn
PY  - 2025
N1  - epub
AB  - Prostate-specific antigen (PSA) is central to referrals for prostate biopsy but has low specificity for aggressive prostate cancer. This study evaluates the 4Kscore® (OPKO Diagnostics) versus total PSA in predicting short- and long-term risks of aggressive prostate cancer.Baseline blood samples from 1,658 men diagnosed with prostate cancer (median diagnosis time = 8.6 years) and 1,658 matched controls in the European Prospective Investigation into Cancer and Nutrition (EPIC) were analyzed. Discrimination for the 4Kscore and total PSA was assessed using the area under the curve (AUC) with 95
LB  - PUB:(DE-HGF)16
C6  - pmid:40844611
DO  - DOI:10.1158/1055-9965.EPI-24-1877
UR  - https://inrepo02.dkfz.de/record/304090
ER  -