%0 Journal Article
%A Gottschlich, Anna Sophia
%A Ernst, Jana
%A Milde, Till
%A Gruhn, Bernd
%T Comparative study of liposomal amphotericin B, posaconazole, and micafungin for primary antifungal prophylaxis in pediatric patients with acute leukemia.
%J Journal of cancer research and clinical oncology
%V 151
%N 8
%@ 0301-1585
%C Heidelberg
%I Springer
%M DKFZ-2025-01763
%P 235
%D 2025
%X Invasive fungal diseases (IFDs) are a significant cause of morbidity and mortality in pediatric patients with hematologic malignancies including acute leukemia. Our study aimed to compare the efficacy of liposomal amphotericin B (L-AMB), posaconazole or micafungin as primary antifungal prophylaxis (PAP) in pediatric patients with acute leukemia.This retrospective observational study enrolled 95 pediatric patients with acute lymphoblastic leukemia (n = 70) or acute myeloid leukemia (n = 25), undergoing chemotherapy, including those undergoing allogeneic hematopoietic stem cell transplantation at the Department of Pediatrics, Jena University Hospital, Jena, Germany. PAP regimens included L-AMB (1 mg/kg/day or 3 mg/kg twice weekly, intravenously), posaconazole (100-300 mg/day, according to blood concentration, orally or intravenously) and micafungin (1 mg/kg/day or 3 mg/kg twice weekly, intravenously). Thirty-four patients (35.8
%K Humans
%K Micafungin: administration & dosage
%K Male
%K Female
%K Child
%K Antifungal Agents: therapeutic use
%K Antifungal Agents: administration & dosage
%K Retrospective Studies
%K Triazoles: administration & dosage
%K Triazoles: therapeutic use
%K Amphotericin B: administration & dosage
%K Amphotericin B: therapeutic use
%K Child, Preschool
%K Adolescent
%K Precursor Cell Lymphoblastic Leukemia-Lymphoma: complications
%K Precursor Cell Lymphoblastic Leukemia-Lymphoma: drug therapy
%K Leukemia, Myeloid, Acute: complications
%K Leukemia, Myeloid, Acute: drug therapy
%K Infant
%K Mycoses: prevention & control
%K Invasive Fungal Infections: prevention & control
%K Acute leukemia (Other)
%K Invasive fungal disease (Other)
%K Liposomal amphotericin B (Other)
%K Micafungin (Other)
%K Pediatric (Other)
%K Posaconazole (Other)
%K Primary antifungal prophylaxis (Other)
%K Micafungin (NLM Chemicals)
%K Antifungal Agents (NLM Chemicals)
%K posaconazole (NLM Chemicals)
%K Triazoles (NLM Chemicals)
%K Amphotericin B (NLM Chemicals)
%K liposomal amphotericin B (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40848057
%R 10.1007/s00432-025-06289-5
%U https://inrepo02.dkfz.de/record/304095