TY  - JOUR
AU  - Gottschlich, Anna Sophia
AU  - Ernst, Jana
AU  - Milde, Till
AU  - Gruhn, Bernd
TI  - Comparative study of liposomal amphotericin B, posaconazole, and micafungin for primary antifungal prophylaxis in pediatric patients with acute leukemia.
JO  - Journal of cancer research and clinical oncology
VL  - 151
IS  - 8
SN  - 0301-1585
CY  - Heidelberg
PB  - Springer
M1  - DKFZ-2025-01763
SP  - 235
PY  - 2025
AB  - Invasive fungal diseases (IFDs) are a significant cause of morbidity and mortality in pediatric patients with hematologic malignancies including acute leukemia. Our study aimed to compare the efficacy of liposomal amphotericin B (L-AMB), posaconazole or micafungin as primary antifungal prophylaxis (PAP) in pediatric patients with acute leukemia.This retrospective observational study enrolled 95 pediatric patients with acute lymphoblastic leukemia (n = 70) or acute myeloid leukemia (n = 25), undergoing chemotherapy, including those undergoing allogeneic hematopoietic stem cell transplantation at the Department of Pediatrics, Jena University Hospital, Jena, Germany. PAP regimens included L-AMB (1 mg/kg/day or 3 mg/kg twice weekly, intravenously), posaconazole (100-300 mg/day, according to blood concentration, orally or intravenously) and micafungin (1 mg/kg/day or 3 mg/kg twice weekly, intravenously). Thirty-four patients (35.8
KW  - Humans
KW  - Micafungin: administration & dosage
KW  - Male
KW  - Female
KW  - Child
KW  - Antifungal Agents: therapeutic use
KW  - Antifungal Agents: administration & dosage
KW  - Retrospective Studies
KW  - Triazoles: administration & dosage
KW  - Triazoles: therapeutic use
KW  - Amphotericin B: administration & dosage
KW  - Amphotericin B: therapeutic use
KW  - Child, Preschool
KW  - Adolescent
KW  - Precursor Cell Lymphoblastic Leukemia-Lymphoma: complications
KW  - Precursor Cell Lymphoblastic Leukemia-Lymphoma: drug therapy
KW  - Leukemia, Myeloid, Acute: complications
KW  - Leukemia, Myeloid, Acute: drug therapy
KW  - Infant
KW  - Mycoses: prevention & control
KW  - Invasive Fungal Infections: prevention & control
KW  - Acute leukemia (Other)
KW  - Invasive fungal disease (Other)
KW  - Liposomal amphotericin B (Other)
KW  - Micafungin (Other)
KW  - Pediatric (Other)
KW  - Posaconazole (Other)
KW  - Primary antifungal prophylaxis (Other)
KW  - Micafungin (NLM Chemicals)
KW  - Antifungal Agents (NLM Chemicals)
KW  - posaconazole (NLM Chemicals)
KW  - Triazoles (NLM Chemicals)
KW  - Amphotericin B (NLM Chemicals)
KW  - liposomal amphotericin B (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40848057
DO  - DOI:10.1007/s00432-025-06289-5
UR  - https://inrepo02.dkfz.de/record/304095
ER  -