%0 Journal Article
%A Pham, Thu Thi
%A Nimptsch, Katharina
%A Aleksandrova, Krasimira
%A Jenab, Mazda
%A Fedirko, Veronika
%A Olsen, Anja
%A Tjønneland, Anne
%A Cadeau, Claire
%A Severi, Gianluca
%A Schulze, Matthias B
%A Turzanski-Fortner, Renée
%A Katzke, Verena
%A Agnoli, Claudia
%A Sacerdote, Carlotta
%A Tumino, Rosario
%A Signoriello, Simona
%A Trobajo-Sanmartín, Camino
%A Gómez, Jesús-Humberto
%A Chirlaque, María-Dolores
%A Sánchez, Maria-Jose
%A Crous-Bou, Marta
%A May, Anne
%A Heath, Alicia
%A Aune, Dagfinn
%A Weiderpass, Elisabete
%A Pischon, Tobias
%T Circulating fatty acid binding protein 4 (FABP-4) concentrations and mortality in individuals with colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study.
%J International journal of cancer
%V nn
%@ 0020-7136
%C Bognor Regis
%I Wiley-Liss
%M DKFZ-2025-01786
%P nn
%D 2025
%Z epub
%X Human fatty acid binding protein-4 (FABP-4), a protein elevated in obesity that promotes colon cancer cell invasiveness and metastasis, may be associated with higher mortality in individuals with colorectal cancer (CRC) and may serve as a mediator of the obesity-mortality association in these individuals. We used a causal diagram to inform covariate selection and applied Cox proportional hazards models to estimate hazard ratios (HRs) for CRC-specific, non-CRC-specific, and all-cause mortality by FABP-4 levels measured in baseline blood samples from 1371 incident CRC cases from the European Prospective Investigation into Cancer and Nutrition cohort. Competing risk analyses were adapted for CRC and non-CRC deaths. Mediation analyses were conducted to estimate total effects (TEs), direct effects (DEs), and mediation proportions (MPs) by FABP-4 of pre-diagnostic body mass index (BMI) on mortality. In the fully adjusted model including BMI, higher circulating FABP-4 concentrations were associated with higher CRC mortality (HRQ4vsQ1 = 1.49; 95
%K EPIC (Other)
%K FABP‐4 (Other)
%K human fatty acid binding protein‐4 (Other)
%K incident colorectal cancer (Other)
%K mortality (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40857027
%R 10.1002/ijc.70090
%U https://inrepo02.dkfz.de/record/304123