TY  - JOUR
AU  - Pham, Thu Thi
AU  - Nimptsch, Katharina
AU  - Aleksandrova, Krasimira
AU  - Jenab, Mazda
AU  - Fedirko, Veronika
AU  - Olsen, Anja
AU  - Tjønneland, Anne
AU  - Cadeau, Claire
AU  - Severi, Gianluca
AU  - Schulze, Matthias B
AU  - Turzanski-Fortner, Renée
AU  - Katzke, Verena
AU  - Agnoli, Claudia
AU  - Sacerdote, Carlotta
AU  - Tumino, Rosario
AU  - Signoriello, Simona
AU  - Trobajo-Sanmartín, Camino
AU  - Gómez, Jesús-Humberto
AU  - Chirlaque, María-Dolores
AU  - Sánchez, Maria-Jose
AU  - Crous-Bou, Marta
AU  - May, Anne
AU  - Heath, Alicia
AU  - Aune, Dagfinn
AU  - Weiderpass, Elisabete
AU  - Pischon, Tobias
TI  - Circulating fatty acid binding protein 4 (FABP-4) concentrations and mortality in individuals with colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study.
JO  - International journal of cancer
VL  - nn
SN  - 0020-7136
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2025-01786
SP  - nn
PY  - 2025
N1  - epub
AB  - Human fatty acid binding protein-4 (FABP-4), a protein elevated in obesity that promotes colon cancer cell invasiveness and metastasis, may be associated with higher mortality in individuals with colorectal cancer (CRC) and may serve as a mediator of the obesity-mortality association in these individuals. We used a causal diagram to inform covariate selection and applied Cox proportional hazards models to estimate hazard ratios (HRs) for CRC-specific, non-CRC-specific, and all-cause mortality by FABP-4 levels measured in baseline blood samples from 1371 incident CRC cases from the European Prospective Investigation into Cancer and Nutrition cohort. Competing risk analyses were adapted for CRC and non-CRC deaths. Mediation analyses were conducted to estimate total effects (TEs), direct effects (DEs), and mediation proportions (MPs) by FABP-4 of pre-diagnostic body mass index (BMI) on mortality. In the fully adjusted model including BMI, higher circulating FABP-4 concentrations were associated with higher CRC mortality (HRQ4vsQ1 = 1.49; 95
KW  - EPIC (Other)
KW  - FABP‐4 (Other)
KW  - human fatty acid binding protein‐4 (Other)
KW  - incident colorectal cancer (Other)
KW  - mortality (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40857027
DO  - DOI:10.1002/ijc.70090
UR  - https://inrepo02.dkfz.de/record/304123
ER  -