% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Pham:304123,
      author       = {T. T. Pham and K. Nimptsch and K. Aleksandrova and M. Jenab
                      and V. Fedirko and A. Olsen and A. Tjønneland and C. Cadeau
                      and G. Severi and M. B. Schulze and R. Turzanski-Fortner$^*$
                      and V. Katzke$^*$ and C. Agnoli and C. Sacerdote and R.
                      Tumino and S. Signoriello and C. Trobajo-Sanmartín and
                      J.-H. Gómez and M.-D. Chirlaque and M.-J. Sánchez and M.
                      Crous-Bou and A. May and A. Heath and D. Aune and E.
                      Weiderpass and T. Pischon},
      title        = {{C}irculating fatty acid binding protein 4 ({FABP}-4)
                      concentrations and mortality in individuals with colorectal
                      cancer in the {E}uropean {P}rospective {I}nvestigation into
                      {C}ancer and {N}utrition study.},
      journal      = {International journal of cancer},
      volume       = {158},
      number       = {3},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2025-01786},
      pages        = {546-559},
      year         = {2026},
      note         = {2026 Feb 1;158(3):546-559},
      abstract     = {Human fatty acid binding protein-4 (FABP-4), a protein
                      elevated in obesity that promotes colon cancer cell
                      invasiveness and metastasis, may be associated with higher
                      mortality in individuals with colorectal cancer (CRC) and
                      may serve as a mediator of the obesity-mortality association
                      in these individuals. We used a causal diagram to inform
                      covariate selection and applied Cox proportional hazards
                      models to estimate hazard ratios (HRs) for CRC-specific,
                      non-CRC-specific, and all-cause mortality by FABP-4 levels
                      measured in baseline blood samples from 1371 incident CRC
                      cases from the European Prospective Investigation into
                      Cancer and Nutrition cohort. Competing risk analyses were
                      adapted for CRC and non-CRC deaths. Mediation analyses were
                      conducted to estimate total effects (TEs), direct effects
                      (DEs), and mediation proportions (MPs) by FABP-4 of
                      pre-diagnostic body mass index (BMI) on mortality. In the
                      fully adjusted model including BMI, higher circulating
                      FABP-4 concentrations were associated with higher CRC
                      mortality (HRQ4vsQ1 = 1.49; $95\%$ CI: 1.11-2.00) and
                      all-cause mortality (HRQ4vsQ1 = 1.49; $95\%$ CI: 1.15-1.93),
                      but not statistically associated with non-CRC mortality
                      (HRQ4vsQ1 = 1.51; $95\%$ CI: 0.82-2.76). The TE and DE per 5
                      kg/m2 of BMI on all-cause mortality were 1.21; $95\%$ CI:
                      1.10-1.34, and 1.13; $95\%$ CI: 1.02-1.26, respectively,
                      with a MP of $34.5\%$ (p = .002) by FABP-4. For CRC-specific
                      and non-CRC-specific mortality, MPs by FABP-4 were $33.7\%$
                      (p = .03) and $36.1\%$ (p = .02), respectively. In
                      conclusion, higher concentrations of FABP-4 were associated
                      with higher CRC-specific and all-cause mortality in
                      individuals with CRC. FABP-4 was a significant partial
                      mediator of the adiposity-mortality relationship in
                      individuals with CRC.},
      keywords     = {EPIC (Other) / FABP‐4 (Other) / human fatty acid binding
                      protein‐4 (Other) / incident colorectal cancer (Other) /
                      mortality (Other)},
      cin          = {C180 / C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C180-20160331 / I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40857027},
      doi          = {10.1002/ijc.70090},
      url          = {https://inrepo02.dkfz.de/record/304123},
}