TY  - JOUR
AU  - Ballhausen, Alexej
AU  - Morano, Federica
AU  - Stahler, Arndt
AU  - Lonardi, Sara
AU  - Kind, Andreas Jay
AU  - Cremolini, Chiara
AU  - Swoboda, Susanna
AU  - Randon, Giovanni
AU  - Horst, David
AU  - Prisciandaro, Michele
AU  - Alig, Annabel Helga Sophie
AU  - Pircher, Chiara Carlotta
AU  - Jarosch, Armin
AU  - Andena, Paola
AU  - Kurreck, Annika
AU  - Chiaramonte, Anna Alessandra
AU  - Stintzing, Sebastian
AU  - Pietrantonio, Filippo
AU  - Modest, Dominik Paul
AU  - Raimondi, Alessandra
TI  - Primary tumor sidedness and negative hyperselection to modulate anti-EGFR-based maintenance strategies in patients with RAS wild-type metastatic colorectal cancer: individual patient data pooled analysis of two randomized clinical trials.
JO  - British journal of cancer
VL  - 133
IS  - 9
SN  - 0007-0920
CY  - Edinburgh
PB  - Nature Publ. Group
M1  - DKFZ-2025-01799
SP  - 1297-1306
PY  - 2025
N1  - 2025 Nov;133(9):1297-1306
AB  - Patients with RAS wild-type (WT), left-sided metastatic colorectal cancer (mCRC), negatively hyperselected for anti-EGFR resistance alterations, benefit most from anti-EGFR-based first-line treatment. The predictive impact of these stratification parameters on maintenance strategy efficacy is unclear.This pooled analysis included individual patient data from the PanaMa (NCT01991873) and Valentino (NCT02476045) phase 2 trials. Patients with RAS WT mCRC received FOLFOX plus Panitumumab induction therapy followed by maintenance with 5-fluorouracil/leucovorin (5-FU/LV) plus Panitumumab vs. 5-FU/LV monotherapy (PanaMa) or Panitumumab monotherapy (Valentino). Outcomes included progression-free survival (PFS) and overall survival (OS). Subgroup analyses examined primary tumor sidedness (left vs. right) and hyperselection status (negative vs. altered).Among 607 patients receiving induction, sidedness and hyperselection status were available for 589 and 511 patients, respectively. Left-sided and negative hyperselected tumors were observed in 80.2
LB  - PUB:(DE-HGF)16
C6  - pmid:40877636
DO  - DOI:10.1038/s41416-025-03164-5
UR  - https://inrepo02.dkfz.de/record/304245
ER  -