TY  - JOUR
AU  - Lehtinen, Tuomas
AU  - Zhang, Luayo
AU  - Sundquist, Kristina
AU  - Sundquist, Jan
AU  - Waterboer, Tim
AU  - Lehtinen, Matti Osmo Antero
AU  - Hemminki, Kari
TI  - Elevated Risk of HPV-Associated Oropharyngeal Cancers in Husbands of Women With Anogenital Cancer.
JO  - Cancer reports
VL  - 8
IS  - 9
SN  - 2573-8348
CY  - Medford, MA
PB  - Wiley
M1  - DKFZ-2025-01801
SP  - e70333
PY  - 2025
N1  - Z999
AB  - Human papillomavirus (HPV) infection is associated with tonsillar and base-of-tongue squamous cell carcinomas (TSCC/BOTSCC). We evaluated the relative risk (RR) of TSCC/BOTSCC in the husbands of women with anogenital cancer using the Swedish family database.The Swedish family database includes 3.5 million families and 16 million individuals identified since 1932 and linked to cancer data from 1958 to 2015. We explored the RR of TSCC/BOTSCC in husbands of women diagnosed with anogenital (anal, vulvar/vaginal, cervical) cancer or cervical carcinoma in situ (CIS) as compared to husbands of controls.The RR of TSCC/BOTSCC in husbands of women with invasive anogenital cancer increased by calendar time and decreasing ages at diagnoses. In 2002-2015, the RR peaked at 5.35 (95
KW  - Humans
KW  - Female
KW  - Papillomavirus Infections: virology
KW  - Papillomavirus Infections: complications
KW  - Papillomavirus Infections: epidemiology
KW  - Middle Aged
KW  - Sweden: epidemiology
KW  - Spouses: statistics & numerical data
KW  - Male
KW  - Adult
KW  - Anus Neoplasms: virology
KW  - Anus Neoplasms: epidemiology
KW  - Oropharyngeal Neoplasms: virology
KW  - Oropharyngeal Neoplasms: epidemiology
KW  - Aged
KW  - Vulvar Neoplasms: virology
KW  - Vulvar Neoplasms: epidemiology
KW  - Risk Factors
KW  - Uterine Cervical Neoplasms: virology
KW  - Uterine Cervical Neoplasms: epidemiology
KW  - Carcinoma, Squamous Cell: virology
KW  - Carcinoma, Squamous Cell: epidemiology
KW  - Papillomaviridae: isolation & purification
KW  - familial cancer (Other)
KW  - head and neck cancer (Other)
KW  - viral infection (Other)
KW  - viral oncology (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40877205
DO  - DOI:10.1002/cnr2.70333
UR  - https://inrepo02.dkfz.de/record/304247
ER  -