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@ARTICLE{Lehtinen:304247,
      author       = {T. Lehtinen and L. Zhang$^*$ and K. Sundquist and J.
                      Sundquist and T. Waterboer$^*$ and M. O. A. Lehtinen$^*$ and
                      K. Hemminki$^*$},
      title        = {{E}levated {R}isk of {HPV}-{A}ssociated {O}ropharyngeal
                      {C}ancers in {H}usbands of {W}omen {W}ith {A}nogenital
                      {C}ancer.},
      journal      = {Cancer reports},
      volume       = {8},
      number       = {9},
      issn         = {2573-8348},
      address      = {Medford, MA},
      publisher    = {Wiley},
      reportid     = {DKFZ-2025-01801},
      pages        = {e70333},
      year         = {2025},
      note         = {Z999},
      abstract     = {Human papillomavirus (HPV) infection is associated with
                      tonsillar and base-of-tongue squamous cell carcinomas
                      (TSCC/BOTSCC). We evaluated the relative risk (RR) of
                      TSCC/BOTSCC in the husbands of women with anogenital cancer
                      using the Swedish family database.The Swedish family
                      database includes 3.5 million families and 16 million
                      individuals identified since 1932 and linked to cancer data
                      from 1958 to 2015. We explored the RR of TSCC/BOTSCC in
                      husbands of women diagnosed with anogenital (anal,
                      vulvar/vaginal, cervical) cancer or cervical carcinoma in
                      situ (CIS) as compared to husbands of controls.The RR of
                      TSCC/BOTSCC in husbands of women with invasive anogenital
                      cancer increased by calendar time and decreasing ages at
                      diagnoses. In 2002-2015, the RR peaked at 5.35 $(95\%$ CI
                      2.21-13.0) in TSCC/BOTSCC cases diagnosed at age < 50 years.
                      In husbands of women with CIS, the RR for TSCC/BOTSCC was
                      2-fold irrespective of time period.Clustering of increased
                      HPV-associated invasive cancer risk in spouses appears to be
                      calendar-time dependent. This introduces a new perspective
                      in cancer science: an increase of familial HPV-associated
                      cancer risk in spouses.},
      keywords     = {Humans / Female / Papillomavirus Infections: virology /
                      Papillomavirus Infections: complications / Papillomavirus
                      Infections: epidemiology / Middle Aged / Sweden:
                      epidemiology / Spouses: statistics $\&$ numerical data /
                      Male / Adult / Anus Neoplasms: virology / Anus Neoplasms:
                      epidemiology / Oropharyngeal Neoplasms: virology /
                      Oropharyngeal Neoplasms: epidemiology / Aged / Vulvar
                      Neoplasms: virology / Vulvar Neoplasms: epidemiology / Risk
                      Factors / Uterine Cervical Neoplasms: virology / Uterine
                      Cervical Neoplasms: epidemiology / Carcinoma, Squamous Cell:
                      virology / Carcinoma, Squamous Cell: epidemiology /
                      Papillomaviridae: isolation $\&$ purification / familial
                      cancer (Other) / head and neck cancer (Other) / viral
                      infection (Other) / viral oncology (Other)},
      cin          = {C050 / D320},
      ddc          = {610},
      cid          = {I:(DE-He78)C050-20160331 / I:(DE-He78)D320-20160331},
      pnm          = {314 - Immunologie und Krebs (POF4-314)},
      pid          = {G:(DE-HGF)POF4-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40877205},
      doi          = {10.1002/cnr2.70333},
      url          = {https://inrepo02.dkfz.de/record/304247},
}