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@ARTICLE{Yi:304253,
      author       = {E. Yi and A. D. Gujar and D. Zhao and K. Suina and X. Jin
                      and K. Pardon and Q. Yu and L. Kagermazova and E. E. Korsah
                      and N. A. Dusseau and J. D. Boeke and A. G. Henssen$^*$ and
                      R. G. W. Verhaak},
      title        = {{S}elective {D}epletion of {C}ancer {C}ells with
                      {E}xtrachromosomal {DNA} via {L}entiviral {I}nfection.},
      journal      = {Cancer research communications},
      volume       = {5},
      number       = {8},
      issn         = {2767-9764},
      address      = {Philadelphia, Pa.},
      publisher    = {American Association for Cancer Research},
      reportid     = {DKFZ-2025-01807},
      pages        = {1458 - 1465},
      year         = {2025},
      abstract     = {Extrachromosomal DNA (ecDNA), a major focal oncogene
                      amplification mode found across cancer, has recently
                      regained attention as an emerging cancer hallmark, with a
                      pervasive presence across cancers. With technical
                      advancements such as high-coverage sequencing and live-cell
                      genome imaging, we can now investigate the behaviors and
                      functions of ecDNA. However, we still lack an understanding
                      of how to eliminate ecDNA. We observed depletion of cells
                      containing ecDNA during lentiviral but not transposon-based
                      transduction, whereas we sought to investigate the mechanism
                      of ecDNA behavior. This discovery may provide critical
                      information on utilizing a lentiviral system in emerging
                      ecDNA research. Additionally, this observation suggests
                      specific sensitivities for cells with ecDNA.ecDNA is an
                      essential factor in cancer progression. We found that a
                      group of cancer cells with ecDNA is selectively depleted
                      after lentiviral infection. This finding provides promise
                      for ecDNA-specific targeting, suggests the need for caution
                      in using lentivirus, and offers alternative ways to study
                      ecDNA.},
      keywords     = {Humans / Lentivirus: genetics / Neoplasms: genetics /
                      Neoplasms: pathology / Cell Line, Tumor / Transduction,
                      Genetic / Lentivirus Infections: genetics / DNA: genetics /
                      DNA (NLM Chemicals)},
      cin          = {BE01},
      ddc          = {610},
      cid          = {I:(DE-He78)BE01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40787829},
      pmc          = {pmc:PMC12392265},
      doi          = {10.1158/2767-9764.CRC-25-0144},
      url          = {https://inrepo02.dkfz.de/record/304253},
}