TY  - JOUR
AU  - Rajtmajerova, Marie
AU  - Ambrozkiewicz, Filip
AU  - Hlavac, Viktor
AU  - Trailin, Andriy
AU  - Cervenkova, Lenka
AU  - Bruha, Jan
AU  - Susova, Simona
AU  - Soucek, Pavel
AU  - Vodicka, Pavel
AU  - Vodickova, Ludmila
AU  - Kubecek, Ondrej
AU  - Filip, Stanislav
AU  - Mallela, Venkata R
AU  - Ye, Wenjing
AU  - Zitricky, Frantisek
AU  - Liska, Vaclav
AU  - Hemminki, Kari
TI  - Genetic differences between primary colorectal cancer and its paired synchronous and metachronous metastases.
JO  - International journal of cancer
VL  - nn
SN  - 0020-7136
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2025-01815
SP  - nn
PY  - 2025
N1  - #LA:Z999# / epub
AB  - As the second most deadly cancerous disease worldwide, colorectal cancer (CRC) stands in the center of scientific interest in hope to develop novel approaches for precise diagnostics and prognosis determination. Metastatic disease remains the main cause of CRC mortality. To investigate the underlying genetic differences between CRC patients with synchronous and metachronous liver metastases, we performed whole-exome sequencing of 210 patient samples using formalin-fixed paraffin-embedded samples from primary tumors and the paired liver metastatic tissue. The analyses included types and levels of mutations and copy number variation. APC and TP53 were the most commonly mutated genes in all samples with differing frequency between primary CRC (both 50
KW  - WES (Other)
KW  - colorectal cancer (Other)
KW  - metachronous liver metastasis (Other)
KW  - synchronous liver metastasis (Other)
KW  - whole‐exome sequencing (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40884237
DO  - DOI:10.1002/ijc.70116
UR  - https://inrepo02.dkfz.de/record/304274
ER  -