%0 Journal Article
%A Hu, Yuqing
%A Kharazmi, Elham
%A Liang, Qunfeng
%A Brenner, Hermann
%A Sundquist, Jan
%A Sundquist, Kristina
%A Fallah, Mahdi
%T Risk of colorectal cancer by family history of both colorectal carcinomas and colorectal polyps: a nationwide cohort study.
%J Cancer communications
%V nn
%@ 1000-467X
%C Hoboken, NJ
%I Wiley
%M DKFZ-2025-01829
%P nn
%D 2025
%Z #EA:C120#LA:C120# / epub
%X The increased risk of colorectal cancer (CRC) associated with family history of both colorectal in situ or invasive carcinomas (Stage 0 to IV) and colorectal polyps is attributed solely to family history of CRC, resulting in an underestimation of the actual risk. We aimed to assess the association between overall and early-onset CRC (EOCRC) risk and family history of both colorectal carcinomas and polyps.We conducted a nationwide cohort study leveraging Swedish family-cancer datasets with follow-up from 1964 to 2018. Standardized incidence ratios (SIRs) were calculated to estimate the risk of CRC and EOCRC among individuals with a family history of both colorectal polyps and carcinomas.We followed up 13,432,205 individuals for up to 54 years. The risk of overall CRC was 2.2 times increased in individuals with 1 first-degree relative (FDR) with one-time polyp diagnosis and an additional FDR with carcinoma (95
%K colorectal cancer (Other)
%K colorectal polyp (Other)
%K early‐onset colorectal cancer (Other)
%K family history (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40898381
%R 10.1002/cac2.70059
%U https://inrepo02.dkfz.de/record/304293