TY  - JOUR
AU  - Hu, Yuqing
AU  - Kharazmi, Elham
AU  - Liang, Qunfeng
AU  - Brenner, Hermann
AU  - Sundquist, Jan
AU  - Sundquist, Kristina
AU  - Fallah, Mahdi
TI  - Risk of colorectal cancer by family history of both colorectal carcinomas and colorectal polyps: a nationwide cohort study.
JO  - Cancer communications
VL  - nn
SN  - 1000-467X
CY  - Hoboken, NJ
PB  - Wiley
M1  - DKFZ-2025-01829
SP  - nn
PY  - 2025
N1  - #EA:C120#LA:C120# / epub
AB  - The increased risk of colorectal cancer (CRC) associated with family history of both colorectal in situ or invasive carcinomas (Stage 0 to IV) and colorectal polyps is attributed solely to family history of CRC, resulting in an underestimation of the actual risk. We aimed to assess the association between overall and early-onset CRC (EOCRC) risk and family history of both colorectal carcinomas and polyps.We conducted a nationwide cohort study leveraging Swedish family-cancer datasets with follow-up from 1964 to 2018. Standardized incidence ratios (SIRs) were calculated to estimate the risk of CRC and EOCRC among individuals with a family history of both colorectal polyps and carcinomas.We followed up 13,432,205 individuals for up to 54 years. The risk of overall CRC was 2.2 times increased in individuals with 1 first-degree relative (FDR) with one-time polyp diagnosis and an additional FDR with carcinoma (95
KW  - colorectal cancer (Other)
KW  - colorectal polyp (Other)
KW  - early‐onset colorectal cancer (Other)
KW  - family history (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40898381
DO  - DOI:10.1002/cac2.70059
UR  - https://inrepo02.dkfz.de/record/304293
ER  -