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@ARTICLE{Hu:304293,
      author       = {Y. Hu$^*$ and E. Kharazmi and Q. Liang$^*$ and H.
                      Brenner$^*$ and J. Sundquist and K. Sundquist and M.
                      Fallah$^*$},
      title        = {{R}isk of colorectal cancer by family history of both
                      colorectal carcinomas and colorectal polyps: a nationwide
                      cohort study.},
      journal      = {Cancer communications},
      volume       = {nn},
      issn         = {1000-467X},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DKFZ-2025-01829},
      pages        = {nn},
      year         = {2025},
      note         = {#EA:C120#LA:C120# / epub},
      abstract     = {The increased risk of colorectal cancer (CRC) associated
                      with family history of both colorectal in situ or invasive
                      carcinomas (Stage 0 to IV) and colorectal polyps is
                      attributed solely to family history of CRC, resulting in an
                      underestimation of the actual risk. We aimed to assess the
                      association between overall and early-onset CRC (EOCRC) risk
                      and family history of both colorectal carcinomas and
                      polyps.We conducted a nationwide cohort study leveraging
                      Swedish family-cancer datasets with follow-up from 1964 to
                      2018. Standardized incidence ratios (SIRs) were calculated
                      to estimate the risk of CRC and EOCRC among individuals with
                      a family history of both colorectal polyps and carcinomas.We
                      followed up 13,432,205 individuals for up to 54 years. The
                      risk of overall CRC was 2.2 times increased in individuals
                      with 1 first-degree relative (FDR) with one-time polyp
                      diagnosis and an additional FDR with carcinoma $(95\%$ CI =
                      2.1-2.3; EOCRC SIR = 2.9 $[95\%$ CI = 2.4-3.4]). The risk
                      was significantly higher in individuals with 1 FDR with
                      repeated polyp diagnoses (≥2 times) and an additional FDR
                      with carcinoma (overall SIR = 2.9 $[95\%$ CI = 2.7-3.1];
                      EOCRC SIR = 5.4 $[95\%$ CI = 3.9-6.4]). A similar risk was
                      observed in individuals with ≥2 FDRs with one-time polyp
                      diagnosis and an additional FDR with carcinoma (overall SIR
                      = 2.9 $[95\%$ CI = 2.4-3.4]; EOCRC SIR = 5.3 $[95\%$ CI =
                      3.0-8.6]). Individuals with ≥2 FDRs with repeated polyp
                      diagnoses and an additional FDR with carcinoma had a
                      5.0-fold overall risk $(95\%$ CI = 4.3-5.7) and a 13.8-fold
                      EOCRC risk $(95\%$ CI = 9.7-20.1). Younger age at
                      polyp/carcinoma diagnoses, and more relatives with polyps
                      and carcinomas were associated with higher CRC
                      risk.Individuals with a family history of both colorectal
                      polyps and carcinomas are at significantly increased risk of
                      CRC, especially EOCRC. The risk increased with frequent
                      polyp diagnoses, younger age at first polyp/carcinoma
                      diagnoses, and the number of relatives with
                      polyps/carcinomas. This study highlights the importance of
                      considering both colorectal polyps and carcinomas in family
                      history when assessing CRC risk. These findings could
                      supplement current screening guidelines.},
      keywords     = {colorectal cancer (Other) / colorectal polyp (Other) /
                      early‐onset colorectal cancer (Other) / family history
                      (Other)},
      cin          = {C120 / C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C120-20160331 / I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40898381},
      doi          = {10.1002/cac2.70059},
      url          = {https://inrepo02.dkfz.de/record/304293},
}