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| 001 | 304293 | ||
| 005 | 20250904114814.0 | ||
| 024 | 7 | _ | |a 10.1002/cac2.70059 |2 doi |
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| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Hu, Yuqing |0 P:(DE-He78)d59be7ca3c039f32929e64c64ace25d9 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Risk of colorectal cancer by family history of both colorectal carcinomas and colorectal polyps: a nationwide cohort study. |
| 260 | _ | _ | |a Hoboken, NJ |c 2025 |b Wiley |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1756967992_27123 |2 PUB:(DE-HGF) |
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| 500 | _ | _ | |a #EA:C120#LA:C120# / epub |
| 520 | _ | _ | |a The increased risk of colorectal cancer (CRC) associated with family history of both colorectal in situ or invasive carcinomas (Stage 0 to IV) and colorectal polyps is attributed solely to family history of CRC, resulting in an underestimation of the actual risk. We aimed to assess the association between overall and early-onset CRC (EOCRC) risk and family history of both colorectal carcinomas and polyps.We conducted a nationwide cohort study leveraging Swedish family-cancer datasets with follow-up from 1964 to 2018. Standardized incidence ratios (SIRs) were calculated to estimate the risk of CRC and EOCRC among individuals with a family history of both colorectal polyps and carcinomas.We followed up 13,432,205 individuals for up to 54 years. The risk of overall CRC was 2.2 times increased in individuals with 1 first-degree relative (FDR) with one-time polyp diagnosis and an additional FDR with carcinoma (95% CI = 2.1-2.3; EOCRC SIR = 2.9 [95% CI = 2.4-3.4]). The risk was significantly higher in individuals with 1 FDR with repeated polyp diagnoses (≥2 times) and an additional FDR with carcinoma (overall SIR = 2.9 [95% CI = 2.7-3.1]; EOCRC SIR = 5.4 [95% CI = 3.9-6.4]). A similar risk was observed in individuals with ≥2 FDRs with one-time polyp diagnosis and an additional FDR with carcinoma (overall SIR = 2.9 [95% CI = 2.4-3.4]; EOCRC SIR = 5.3 [95% CI = 3.0-8.6]). Individuals with ≥2 FDRs with repeated polyp diagnoses and an additional FDR with carcinoma had a 5.0-fold overall risk (95% CI = 4.3-5.7) and a 13.8-fold EOCRC risk (95% CI = 9.7-20.1). Younger age at polyp/carcinoma diagnoses, and more relatives with polyps and carcinomas were associated with higher CRC risk.Individuals with a family history of both colorectal polyps and carcinomas are at significantly increased risk of CRC, especially EOCRC. The risk increased with frequent polyp diagnoses, younger age at first polyp/carcinoma diagnoses, and the number of relatives with polyps/carcinomas. This study highlights the importance of considering both colorectal polyps and carcinomas in family history when assessing CRC risk. These findings could supplement current screening guidelines. |
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| 650 | _ | 7 | |a colorectal cancer |2 Other |
| 650 | _ | 7 | |a colorectal polyp |2 Other |
| 650 | _ | 7 | |a early‐onset colorectal cancer |2 Other |
| 650 | _ | 7 | |a family history |2 Other |
| 700 | 1 | _ | |a Kharazmi, Elham |b 1 |
| 700 | 1 | _ | |a Liang, Qunfeng |0 P:(DE-He78)59bc83ea3f8c2a5ef6118233f87b5e68 |b 2 |u dkfz |
| 700 | 1 | _ | |a Brenner, Hermann |0 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2 |b 3 |u dkfz |
| 700 | 1 | _ | |a Sundquist, Jan |b 4 |
| 700 | 1 | _ | |a Sundquist, Kristina |b 5 |
| 700 | 1 | _ | |a Fallah, Mahdi |0 P:(DE-He78)b510b884502b619724039bf33fdae68a |b 6 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1002/cac2.70059 |g p. cac2.70059 |0 PERI:(DE-600)2922913-3 |p nn |t Cancer communications |v nn |y 2025 |x 1000-467X |
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