% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{DelaCruz:304469,
      author       = {F. S. Dela Cruz and E. A. Stewart and D. Surdez and J. D.
                      Daley and A. Soragni and E. M. Tomazou and J. Alvarez-Perez
                      and T. Y. Feinberg and J. F. Amatruda and S. S. Ganapathi
                      and J. E. Ohm and C. M. Heske and S. Cohen-Gogo and D. Pesic
                      and J. O. Nash and A. Shlien and E. A. Roundhill and S. A.
                      Burchill and B. D. Crompton and E. R. Lawlor and D. M. Loeb
                      and O. Delattre and J. Mora and K. Scotlandi and D. R. Reed
                      and P. J. Grohar and T. Grünewald$^*$ and H. Kovar and K.
                      M. Bailey},
      title        = {{A}dvancing preclinical biology for {E}wing {S}arcoma: an
                      international effort.},
      journal      = {Molecular cancer therapeutics},
      volume       = {nn},
      issn         = {1535-7163},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2025-01862},
      pages        = {nn},
      year         = {2025},
      note         = {epub},
      abstract     = {Ewing sarcoma (EwS) is an aggressive bone and soft tissue
                      cancer affecting adolescents and young adults. In vitro and
                      in vivo models of EwS have been instrumental in advancing
                      our understanding of EwS biology and essential in evaluating
                      potential therapies, particularly for metastatic or relapsed
                      disease where effective treatment options remain limited.
                      Through an international collaborative effort between the
                      Children's Oncology Group (COG) Bone Tumor Committee and the
                      Euro Ewing Consortium (EEC), we review the current landscape
                      of preclinical modeling used in EwS research encompassing
                      both in vitro (cell lines and tumor organoids) and in vivo
                      (mouse and non-mammalian xenografts) model systems. We
                      discuss factors that can influence experimental results,
                      provide testing considerations for both in vitro and in vivo
                      studies, and descriptions of existing preclinical data
                      repositories. We highlight current needs in EwS modeling and
                      the importance of enhanced international cooperative
                      research and patient advocacy efforts which will be critical
                      in expanding our resources of biologically-relevant EwS
                      models to enable translation of preclinical findings into
                      effective therapeutic strategies for EwS patients.},
      cin          = {B410 / HD01},
      ddc          = {570},
      cid          = {I:(DE-He78)B410-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40911901},
      doi          = {10.1158/1535-7163.MCT-25-0428},
      url          = {https://inrepo02.dkfz.de/record/304469},
}