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@ARTICLE{Renovanz:304494,
      author       = {M. Renovanz and M. Hippler and R. Kuchen and L. Doerner and
                      D. Rieger and J. P. Steinbach$^*$ and M. W.
                      Ronellenfitsch$^*$ and M. Voss$^*$ and A. F. Kessler and V.
                      Nickl and M. Misch and J. S. Onken and M. Rapp and M.
                      Nadji-Ohl and M. Mehlitz and J. Meixensberger and M. K.
                      Fehrenbach and N. Keric and F. Ringel and J. Coburger and C.
                      W. Lucas and J. Wehinger and F. Schmidt-Graf and J. Gempt
                      and M. Tatagiba and G. Tabatabai and M. Schranz and S.
                      Singer},
      title        = {{P}hysician-led versus questionnaire-based psychosocial
                      screening in adults with high-grade glioma: a
                      cluster-randomized controlled trial ({GLIOPT}).},
      journal      = {Journal of neuro-oncology},
      volume       = {nn},
      issn         = {0167-594X},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V},
      reportid     = {DKFZ-2025-01883},
      pages        = {nn},
      year         = {2025},
      note         = {epub},
      abstract     = {Patients diagnosed with high-grade gliomas (HGG) often
                      experience substantial psychosocial dis-tress. However, due
                      to neurological and neurocognitive deficits its assessment
                      remains challenging, and needs remain unmet. We compared a
                      novel face-to-face assessment during doctor-patient
                      conversations with questionnaire-based screening.In this
                      multicenter, two-arm cluster-randomized study involving 13
                      centers patients in the interven-tion group (IG) were
                      screened for distress via physician-patient conversations,
                      while the control group (CG) completed the Distress
                      Thermometer. Primary outcome was the proportion of patients
                      with poor emotional functioning (measured with the EORTC
                      Quality of Life Questionnaire) who received specialized
                      psychosocial care (PC) within 3 months. Data were collected
                      via patient and physician reports and medical records.
                      Analysis employed mixed models logistic regression.In total,
                      763 patients were enrolled at baseline, and 506 completed
                      the follow-up. The emotional functioning was poor in 302/506
                      $(59.7\%).$ The frequency of patients reporting PC
                      utilization was comparable between groups (IG 93/168,
                      $55.4\%$ vs. CG 87/134, $64.9\%,$ odds ratio (OR) =0.67,
                      $95\%$ confidence interval (CI)=0.40-1.11, p=0.115).
                      Likewise, the provision of information about special-ized
                      psycho-oncological care was similar (IG 112/168, $66.7\%$
                      vs. CG 94/134, $70.1\%,$ OR=0.95, $95\%CI=0.39-2.29,$
                      p=0.904).Physician-led, face-to-face distress screening was
                      not superior to questionnaire-based screening in
                      facilitating psychosocial care referrals. Nonetheless, it
                      represents a feasible and patient-centered alternative,
                      particularly for patients with high-grade gliomas suffering
                      from neurocognitive or func-tional deficits.},
      keywords     = {Assessment (Other) / Distress (Other) / High-grade glioma
                      (Other) / Primary brain tumor patients (Other) /
                      Psychosocial burden (Other) / Psychosocial care (Other) /
                      Screening (Other) / Supportive care needs (Other)},
      cin          = {FM01},
      ddc          = {610},
      cid          = {I:(DE-He78)FM01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40931258},
      doi          = {10.1007/s11060-025-05223-6},
      url          = {https://inrepo02.dkfz.de/record/304494},
}