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@ARTICLE{Sakthivelu:304496,
      author       = {V. Sakthivelu and A. Schmitt and F. Odenthal and K. Ndoci
                      and M. Touet and A. H. Shaib and A. Chihab and G. A. Wani
                      and P. Nieper and G. G. Hartmann and I. Pintelon and I.
                      Kisis and M. Boecker and N. M. Eckert and M. Ianicelli
                      Caiaffa and O. Ibruli and J. Weber and R. Maresch and C. M.
                      Bebber and A. Chitsaz and A. Lütz and M. Kim Alves
                      Carpinteiro and K. M. Morris and C. A. Franchino and J. Benz
                      and L. Pérez-Revuelta and J. A. Soriano-Campos and M. A.
                      Huetzen and J. Goergens and M. Jevtic and H. M.
                      Jahn-Kelleter and H. Zempel and A. Placzek and A. A.
                      Hennrich and K.-K. Conzelmann and H. L. Tumbrink and P.
                      Hunold and J. Isensee and L. Werr and F. Gaedke and A.
                      Schauss and M. Minère and M. Müller and H. Fenselau and Y.
                      Liu and A. Heimsoeth and G. S. Gülcüler Balta and H.
                      Walczak and C. Frezza and R. D. Jachimowicz and J. George
                      and M. Schmiel and J. Brägelmann and T. Hucho and S. von
                      Karstedt and M. Peifer and A. Annibaldi and R.
                      Hänsel-Hertsch and T. Persigehl and H. Grüll and M.
                      Sos$^*$ and G. Reifenberger and M. Fischer and D. Adriaensen
                      and R. Büttner and J. Sage and I. Brouns and R. Rad and R.
                      K. Thomas and M. Anstötz and S. O. Rizzoli and M. Bergami
                      and E. Motori and H. C. Reinhardt$^*$ and F. Beleggia},
      title        = {{F}unctional synapses between neurons and small cell lung
                      cancer.},
      journal      = {Nature},
      volume       = {nn},
      issn         = {0028-0836},
      address      = {London [u.a.]},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2025-01885},
      pages        = {nn},
      year         = {2025},
      note         = {epub},
      abstract     = {Small cell lung cancer (SCLC) is a highly aggressive type
                      of lung cancer, characterized by rapid proliferation, early
                      metastatic spread, frequent early relapse and a high
                      mortality rate1-3. Recent evidence has suggested that
                      innervation has an important role in the development and
                      progression of several types of cancer4,5. Cancer-to-neuron
                      synapses have been reported in gliomas6,7, but whether
                      peripheral tumours can form such structures is unknown. Here
                      we show that SCLC cells can form functional synapses and
                      receive synaptic transmission. Using in vivo insertional
                      mutagenesis screening in conjunction with cross-species
                      genomic and transcriptomic validation, we identified
                      neuronal, synaptic and glutamatergic signalling gene sets in
                      mouse and human SCLC. Further experiments revealed the
                      ability of SCLC cells to form synaptic structures with
                      neurons in vitro and in vivo. Electrophysiology and
                      optogenetic experiments confirmed that cancer cells can
                      receive NMDA receptor- and GABAA receptor-mediated synaptic
                      inputs. Fitting with a potential oncogenic role of
                      neuron-SCLC interactions, we showed that SCLC cells derive a
                      proliferation advantage when co-cultured with vagal sensory
                      or cortical neurons. Moreover, inhibition of glutamate
                      signalling had therapeutic efficacy in an autochthonous
                      mouse model of SCLC. Therefore, following malignant
                      transformation, SCLC cells seem to hijack synaptic
                      signalling to promote tumour growth, thereby exposing a new
                      route for therapeutic intervention.},
      cin          = {MU01 / ED01},
      ddc          = {500},
      cid          = {I:(DE-He78)MU01-20160331 / I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40931078},
      doi          = {10.1038/s41586-025-09434-9},
      url          = {https://inrepo02.dkfz.de/record/304496},
}