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@ARTICLE{Ebner:304506,
      author       = {R. Ebner and J. Braach and J. Rübenthaler and C. C. Cyran
                      and G. T. Sheikh and M. Brendel$^*$ and N. L. Albert$^*$ and
                      R. Tiling and T. Greve and A. Hinterberger and M. P.
                      Fabritius and N. Fink and J. Ricke and R. A. Werner and F.
                      Grawe},
      title        = {{R}etrospective {E}valuation of the {C}orrelation {B}etween
                      {S}omatostatin {R}eceptor {PET}/{CT} and {H}istopathology in
                      {P}atients with {S}uspected {I}ntracranial {M}eningiomas.},
      journal      = {Journal of nuclear medicine},
      volume       = {nn},
      issn         = {0097-9058},
      address      = {New York, NY},
      publisher    = {Soc.},
      reportid     = {DKFZ-2025-01894},
      pages        = {nn},
      year         = {2025},
      note         = {epub},
      abstract     = {The aim of this retrospective study was to evaluate the
                      correlation between findings from somatostatin receptor
                      (SSTR) PET/CT and histopathology in patients with suspected
                      intracranial meningiomas. Methods: We conducted a
                      retrospective analysis of 8,077 SSTR imaging studies
                      recorded in our institutional database between 2006 and
                      2021. In total, 223 SSTR PET/CT scans were performed for
                      suspected meningioma, and 240 lesions were matched with
                      histopathology results within 4 mo. Reports from SSTR PET/CT
                      scans and histopathology were retrospectively reviewed to
                      assess the presence of intracranial meningiomas. The
                      positive and negative predictive values, sensitivity,
                      specificity, and overall diagnostic accuracy of SSTR PET/CT
                      were calculated. The SUVmax, SUVmean, and SUVpeak were
                      determined for each lesion. Results: In 222 $(92.5\%)$ of
                      240 lesions, meningioma was accurately identified by SSTR
                      PET/CT and confirmed by histopathology. In 7 cases
                      $(2.9\%),$ SSTR PET/CT suspected meningioma was not
                      confirmed by histopathology (false-positive). Furthermore,
                      in 11 cases $(5\%),$ meningioma was neither suspected by
                      SSTR PET/CT nor confirmed by histopathology (true-negative
                      result). There were no false-negative findings in our
                      cohort. SSTR PET/CT demonstrated a sensitivity of $100\%$
                      $(95\%$ CI, $98.4\%-100\%)$ and a specificity of $61.1\%$
                      $(95\%$ CI, $35.8\%-82.7\%)$ in detecting meningiomas.
                      Positive predictive value was $96.9\%$ $(95\%$ CI,
                      $93.8\%-98.8\%),$ and negative predictive value was $100\%$
                      $(95\%$ CI, $71.5\%-100\%).$ The overall diagnostic accuracy
                      was $97.1\%.$ The receiver-operating-characteristic analysis
                      for SUVmax in predicting histopathology results showed an
                      area under the curve of $94\%,$ indicating an excellent
                      ability of SUVmax to distinguish between positive and
                      negative histopathologic findings. Conclusion: SSTR PET/CT
                      is a precise imaging modality for detecting intracranial
                      meningiomas, as demonstrated by its high sensitivity.
                      However, in $2.9\%$ of cases, despite a positive PET/CT
                      result, histopathology did not confirm the presence of a
                      meningioma. Integration of MRI, histopathology, and SSTR
                      PET/CT supports informed treatment decisions.},
      keywords     = {PET (Other) / histopathology (Other) / magnetic resonance
                      imaging (Other) / meningioma (Other) / somatostatin receptor
                      (Other)},
      cin          = {MU01},
      ddc          = {610},
      cid          = {I:(DE-He78)MU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40935608},
      doi          = {10.2967/jnumed.125.270115},
      url          = {https://inrepo02.dkfz.de/record/304506},
}