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| Home > Publications database > Retrospective Evaluation of the Correlation Between Somatostatin Receptor PET/CT and Histopathology in Patients with Suspected Intracranial Meningiomas. > print |
| 001 | 304506 | ||
| 005 | 20250914022702.0 | ||
| 024 | 7 | _ | |a 10.2967/jnumed.125.270115 |2 doi |
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| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Ebner, Ricarda |b 0 |
| 245 | _ | _ | |a Retrospective Evaluation of the Correlation Between Somatostatin Receptor PET/CT and Histopathology in Patients with Suspected Intracranial Meningiomas. |
| 260 | _ | _ | |a New York, NY |c 2025 |b Soc. |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
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| 500 | _ | _ | |a epub |
| 520 | _ | _ | |a The aim of this retrospective study was to evaluate the correlation between findings from somatostatin receptor (SSTR) PET/CT and histopathology in patients with suspected intracranial meningiomas. Methods: We conducted a retrospective analysis of 8,077 SSTR imaging studies recorded in our institutional database between 2006 and 2021. In total, 223 SSTR PET/CT scans were performed for suspected meningioma, and 240 lesions were matched with histopathology results within 4 mo. Reports from SSTR PET/CT scans and histopathology were retrospectively reviewed to assess the presence of intracranial meningiomas. The positive and negative predictive values, sensitivity, specificity, and overall diagnostic accuracy of SSTR PET/CT were calculated. The SUVmax, SUVmean, and SUVpeak were determined for each lesion. Results: In 222 (92.5%) of 240 lesions, meningioma was accurately identified by SSTR PET/CT and confirmed by histopathology. In 7 cases (2.9%), SSTR PET/CT suspected meningioma was not confirmed by histopathology (false-positive). Furthermore, in 11 cases (5%), meningioma was neither suspected by SSTR PET/CT nor confirmed by histopathology (true-negative result). There were no false-negative findings in our cohort. SSTR PET/CT demonstrated a sensitivity of 100% (95% CI, 98.4%-100%) and a specificity of 61.1% (95% CI, 35.8%-82.7%) in detecting meningiomas. Positive predictive value was 96.9% (95% CI, 93.8%-98.8%), and negative predictive value was 100% (95% CI, 71.5%-100%). The overall diagnostic accuracy was 97.1%. The receiver-operating-characteristic analysis for SUVmax in predicting histopathology results showed an area under the curve of 94%, indicating an excellent ability of SUVmax to distinguish between positive and negative histopathologic findings. Conclusion: SSTR PET/CT is a precise imaging modality for detecting intracranial meningiomas, as demonstrated by its high sensitivity. However, in 2.9% of cases, despite a positive PET/CT result, histopathology did not confirm the presence of a meningioma. Integration of MRI, histopathology, and SSTR PET/CT supports informed treatment decisions. |
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| 650 | _ | 7 | |a PET |2 Other |
| 650 | _ | 7 | |a histopathology |2 Other |
| 650 | _ | 7 | |a magnetic resonance imaging |2 Other |
| 650 | _ | 7 | |a meningioma |2 Other |
| 650 | _ | 7 | |a somatostatin receptor |2 Other |
| 700 | 1 | _ | |a Braach, Jana |b 1 |
| 700 | 1 | _ | |a Rübenthaler, Johannes |b 2 |
| 700 | 1 | _ | |a Cyran, Clemens C |b 3 |
| 700 | 1 | _ | |a Sheikh, Gabriel T |b 4 |
| 700 | 1 | _ | |a Brendel, Mattias |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Albert, Nathalie L |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Tiling, Reinhold |b 7 |
| 700 | 1 | _ | |a Greve, Tobias |b 8 |
| 700 | 1 | _ | |a Hinterberger, Anna |b 9 |
| 700 | 1 | _ | |a Fabritius, Matthias P |b 10 |
| 700 | 1 | _ | |a Fink, Nicola |b 11 |
| 700 | 1 | _ | |a Ricke, Jens |b 12 |
| 700 | 1 | _ | |a Werner, Rudolf A |b 13 |
| 700 | 1 | _ | |a Grawe, Freba |b 14 |
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