% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Paret:304578,
      author       = {C. Paret$^*$ and A. Wingerter and L. Seidmann and A.
                      Ustjanzew and S. Sathyamurthy$^*$ and J. Ludwig$^*$ and P.
                      Schwickerath$^*$ and C. Brignole and F. Pastorino and S.
                      Wagner and K. El Malki and W. Roth and R. Sandhoff$^*$ and
                      J. Faber$^*$},
      title        = {{G}anglioside {P}rofiling {U}ncovers {D}istinct {P}atterns
                      in {H}igh-{R}isk {N}euroblastoma.},
      journal      = {International journal of molecular sciences},
      volume       = {26},
      number       = {17},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {DKFZ-2025-01901},
      pages        = {8431},
      year         = {2025},
      note         = {#LA:A411#},
      abstract     = {High-risk (HR) neuroblastoma (NBL) patients often receive
                      standardized treatment despite wide variations in clinical
                      outcomes, underscoring the need for improved stratification
                      tools. A distinguishing feature of NBL is the
                      patient-specific expression of gangliosides (GGs),
                      particularly GD2, which may serve as biomarkers. We analyzed
                      GG profiles in 18 patient-derived tumors and 11 NBL cell
                      lines using thin-layer chromatography and mass spectrometry.
                      Expression of 0-, a-, and b-series GGs was examined and
                      correlated with clinical risk, outcome, and gene expression
                      data. Low-risk (LR) tumors expressed higher levels of
                      complex b-series GGs. In HR tumors, five GG profiles (A-E)
                      were identified. Profile A featured complex b-series GGs; B
                      showed GD2 dominance; C showed synthesis arrest at GM3 or
                      GD3 due to low expression of the GM2/GD2 synthase, encoded
                      by the B4GALNT1 gene; D included complex a- and b-series
                      GGs; and E was marked by GM2 and GD1a prevalence. B4GALNT1
                      expression served as a prognostic marker. Relapsed tumors
                      following anti-GD2 therapy typically exhibited reduced GD2
                      levels, except for one profile A tumor that displayed a
                      ceramide anchor shorter than those found in LR tumors.
                      Astonishingly, the ceramide anchor composition of GD2 itself
                      appears to separate LR and HR NBL, hinting at a role of
                      ceramide synthases in NBL biology. All cell lines expressed
                      GM2, but exhibited very low levels of complex b-series GGs.
                      Profile C was found only in cell lines of the mesenchymal
                      subtype. These findings support further investigation of GG
                      composition and associated enzyme expression as potential
                      biomarkers for risk stratification and treatment response in
                      NBL.},
      keywords     = {B4GALNT1 (Other) / GD2 (Other) / ceramide (Other) /
                      dinutuximab (Other) / gangliosides (Other) / naxitamab
                      (Other) / neuroblastoma (Other)},
      cin          = {FM01 / A411},
      ddc          = {540},
      cid          = {I:(DE-He78)FM01-20160331 / I:(DE-He78)A411-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40943355},
      pmc          = {pmc:PMC12428964},
      doi          = {10.3390/ijms26178431},
      url          = {https://inrepo02.dkfz.de/record/304578},
}