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@ARTICLE{Fabian:304583,
      author       = {A. Fabian and A. Rühle and G. Liegl and J. Domschikowski
                      and M. Trommer and S. Ferdinandus and J.-N. Becker and G.
                      Wurschi and S. Boeke and M. Sonnhoff and C. Grott and L.
                      Käsmann$^*$ and M. Schneider and S. Freitag-Wolf and N. H.
                      Nicolay and D. Krug and S. Nolte},
      title        = {{Q}uality of life in cancer patients at the end of
                      radiotherapy compared to a general population sample in
                      {G}ermany.},
      journal      = {International journal of cancer},
      volume       = {nn},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2025-01906},
      pages        = {nn},
      year         = {2025},
      note         = {epub},
      abstract     = {Germany has one of the highest cancer incidence rates in
                      Europe. Radiotherapy is essential for patients with cancer
                      as $50\%$ have an evidence-based indication for
                      radiotherapy. However, it is unknown how health-related
                      quality of life (HRQoL) of cancer patients undergoing
                      radiotherapy compares to the general population in Germany.
                      Therefore, we conducted a secondary analysis by pooling
                      cross-sectional individual-level data from a multicenter
                      cohort of cancer patients (n = 1052) undergoing radiotherapy
                      across Germany and a normative sample from the German
                      general population (n = 1006). We used the EORTC QLQ-C30 to
                      measure global HRQoL (range: 0-100). Higher scores indicate
                      higher HRQoL. We used ANOVA for univariable and ANCOVA with
                      predefined covariates for multivariable analyses. As per
                      univariable analysis, cancer patients had significantly
                      lower global HRQoL compared with the general population
                      (mean [M] = 54.6 vs. M = 65.9; p < .001). This difference
                      was smaller but persisted in the multivariable analysis (M =
                      56.5 vs. M = 63.5; p < .001). Multivariable analyses
                      stratified by education showed that HRQoL was only lower in
                      cancer patients with medium (M = 56.2 vs. M = 63.0; p <
                      .001) or high education (M = 57.0 vs. M = 66.5; p < .001)
                      compared with the general population. The minimal important
                      difference threshold of seven points was only met in the
                      group with high education. In conclusion, there may be a
                      meaningful gap in HRQoL of cancer patients at the end of
                      radiotherapy compared with the general population, mainly in
                      patients with higher educational levels. Upon validation,
                      this would highlight the need for supportive care and
                      optimized radiotherapy strategies to eventually close the
                      HRQoL gap.},
      keywords     = {general population (Other) / neoplasms (Other) / quality of
                      life (Other) / radiotherapy (Other)},
      cin          = {MU01},
      ddc          = {610},
      cid          = {I:(DE-He78)MU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40938250},
      doi          = {10.1002/ijc.70152},
      url          = {https://inrepo02.dkfz.de/record/304583},
}