TY  - JOUR
AU  - Steinberg-Vorhoff, Hannah Luisa
AU  - Drews, Marcel
AU  - Opitz, Marcel
AU  - Landeghem, Natalie van
AU  - Salhöfer, Luca
AU  - Holtkamp, Mathias
AU  - Li, Yan
AU  - Haubold, Johannes
AU  - Siveke, Jens
AU  - Richly, Heike
AU  - Forsting, Michael
AU  - Schaarschmidt, Benedikt Michael
AU  - Zensen, Sebastian
TI  - Does volume change of the spleen correlate with the therapy response in uveal melanoma patients with liver metastases undergoing hepatic artery infusion chemotherapy?
JO  - Radiology and oncology
VL  - 59
IS  - 3
SN  - 1318-2099
CY  - Warsaw
PB  - Sciendo
M1  - DKFZ-2025-01918
SP  - 383 - 390
PY  - 2025
AB  - Uveal melanoma (UM) patients with liver metastases often undergo hepatic artery infusion therapy (HAIC). Due to diffuse metastatic spread in the liver, patients often develop hepatomegaly and secondary, portal hypertension which may lead to splenomegaly. This study aimed to compare spleen volumetry and the change of spleen volume (SV) for the evaluation of HAIC treatment response.In this study, 179 UM patients (mean age 64.8 ± 11.0y, 53
KW  - Humans
KW  - Uveal Neoplasms: pathology
KW  - Uveal Neoplasms: drug therapy
KW  - Female
KW  - Melanoma: drug therapy
KW  - Melanoma: pathology
KW  - Melanoma: secondary
KW  - Melanoma: diagnostic imaging
KW  - Middle Aged
KW  - Male
KW  - Liver Neoplasms: secondary
KW  - Liver Neoplasms: drug therapy
KW  - Liver Neoplasms: diagnostic imaging
KW  - Infusions, Intra-Arterial
KW  - Spleen: pathology
KW  - Spleen: diagnostic imaging
KW  - Uveal Melanoma
KW  - Aged
KW  - Hepatic Artery
KW  - Organ Size
KW  - Retrospective Studies
KW  - Tomography, X-Ray Computed
KW  - Treatment Outcome
KW  - hepatic artery infusion chemotherapy (Other)
KW  - liver metastases (Other)
KW  - spleen size (Other)
KW  - survival (Other)
KW  - uveal melanoma (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40959926
C2  - pmc:PMC12441889
DO  - DOI:10.2478/raon-2025-0047
UR  - https://inrepo02.dkfz.de/record/304599
ER  -