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@ARTICLE{SteinbergVorhoff:304599,
      author       = {H. L. Steinberg-Vorhoff and M. Drews and M. Opitz and N. v.
                      Landeghem and L. Salhöfer and M. Holtkamp and Y. Li and J.
                      Haubold and J. Siveke$^*$ and H. Richly and M. Forsting and
                      B. M. Schaarschmidt and S. Zensen},
      title        = {{D}oes volume change of the spleen correlate with the
                      therapy response in uveal melanoma patients with liver
                      metastases undergoing hepatic artery infusion chemotherapy?},
      journal      = {Radiology and oncology},
      volume       = {59},
      number       = {3},
      issn         = {1318-2099},
      address      = {Warsaw},
      publisher    = {Sciendo},
      reportid     = {DKFZ-2025-01918},
      pages        = {383 - 390},
      year         = {2025},
      abstract     = {Uveal melanoma (UM) patients with liver metastases often
                      undergo hepatic artery infusion therapy (HAIC). Due to
                      diffuse metastatic spread in the liver, patients often
                      develop hepatomegaly and secondary, portal hypertension
                      which may lead to splenomegaly. This study aimed to compare
                      spleen volumetry and the change of spleen volume (SV) for
                      the evaluation of HAIC treatment response.In this study, 179
                      UM patients (mean age 64.8 ± 11.0y, $53\%$ female) with
                      liver metastases undergoing HAIC were included. Treatment
                      response was analyzed by RECIST 1.1 and SV on CT imaging
                      before and after first HAIC. The correlation of change in
                      spleen and liver volume was analyzed with Spearman test.
                      Overall survival (OS) was calculated as the time from the
                      first HAIC to patient death using Kaplan-Meier test and
                      multivariate analysis was performed for RECIST 1.1 and SV.In
                      the study population, OS was 13.8 months $(95\%$ CI
                      10.6-14.7 months). Change in SV before and after first HAIC
                      was $+4\%$ (interquartile range [IQR] $-4.0\%-12.0\%,$ p =
                      0.49) and showed a weak correlation with OS (r = -0.11, p =
                      0.18). UM patients with progressive disease (PD) according
                      to RECIST 1.1 showed an increase in SV compared to patients
                      with stable disease (SD) (p = 0.04). Compared to RECIST 1.1,
                      SV was not significant prognostic factor that can identify a
                      change in OS.In uveal melanoma patients with liver
                      metastases undergoing HAIC, neither the change of SV nor
                      splenomegaly could be identified as prognostic factors for
                      OS.},
      keywords     = {Humans / Uveal Neoplasms: pathology / Uveal Neoplasms: drug
                      therapy / Female / Melanoma: drug therapy / Melanoma:
                      pathology / Melanoma: secondary / Melanoma: diagnostic
                      imaging / Middle Aged / Male / Liver Neoplasms: secondary /
                      Liver Neoplasms: drug therapy / Liver Neoplasms: diagnostic
                      imaging / Infusions, Intra-Arterial / Spleen: pathology /
                      Spleen: diagnostic imaging / Uveal Melanoma / Aged / Hepatic
                      Artery / Organ Size / Retrospective Studies / Tomography,
                      X-Ray Computed / Treatment Outcome / hepatic artery infusion
                      chemotherapy (Other) / liver metastases (Other) / spleen
                      size (Other) / survival (Other) / uveal melanoma (Other)},
      cin          = {ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40959926},
      pmc          = {pmc:PMC12441889},
      doi          = {10.2478/raon-2025-0047},
      url          = {https://inrepo02.dkfz.de/record/304599},
}