%0 Journal Article
%A Maia, Ana
%A Schuhmacher, Juliane
%A Nadalin, Silvio
%A Königsrainer, Alfred
%A Thiel, Karolin
%A Nelde, Annika
%A Zinser, Raphael S
%A Schroeder, Christopher
%A Mattern, Sven
%A Singer, Stephan
%A Bösmüller, Hans
%A Rammensee, Hans-Georg
%A Löffler, Markus W
%A Gouttefangeas, Cécile
%T Exceptional tumor-free survival of a patient with metastatic intrahepatic cholangiocarcinoma after surgery and personalized peptide vaccination: revisiting a striking case.
%J Journal for ImmunoTherapy of Cancer
%V 13
%N 10
%@ 2051-1426
%C London
%I BioMed Central
%M DKFZ-2025-02068
%P e012107
%D 2025
%X Cholangiocarcinomas are rare but aggressive liver tumors of high lethality with scarce treatment options. Here we report on the follow-up of a patient diagnosed with an intrahepatic cholangiocarcinoma who experienced repeated tumor recurrences including distant metastasis, therefore facing a dismal prognosis. At present, this patient is tumor-free for more than 8 years following repeated surgery and application of two successive personalized vaccines. In-depth functional immune cell analyses revealed a dominant CD4+ T-cell response against the vaccine antigens with infiltration of the tumor site and immune responses prevailing for years following the last vaccine administration. Additionally, spontaneous tumor neoantigen-specific CD4+ and CD8+ T-cell responses have been detected, which might have contributed to the outstanding outcome witnessed in this patient. This case report highlights vaccination strategies targeting non-mutated antigens as well as the increasingly recognized central role of antitumor CD4+ T cells.
%K Humans
%K Cholangiocarcinoma: therapy
%K Cholangiocarcinoma: pathology
%K Cholangiocarcinoma: immunology
%K Cholangiocarcinoma: surgery
%K Bile Duct Neoplasms: therapy
%K Bile Duct Neoplasms: pathology
%K Bile Duct Neoplasms: immunology
%K Cancer Vaccines: therapeutic use
%K Male
%K Middle Aged
%K Precision Medicine: methods
%K Vaccines, Subunit: therapeutic use
%K Disease-Free Survival
%K CD4+T cells (Other)
%K cancer vaccine (Other)
%K case report (Other)
%K metastatic cholangiocarcinoma (Other)
%K Cancer Vaccines (NLM Chemicals)
%K Vaccines, Subunit (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41067882
%R 10.1136/jitc-2025-012107
%U https://inrepo02.dkfz.de/record/305222