TY  - JOUR
AU  - Maia, Ana
AU  - Schuhmacher, Juliane
AU  - Nadalin, Silvio
AU  - Königsrainer, Alfred
AU  - Thiel, Karolin
AU  - Nelde, Annika
AU  - Zinser, Raphael S
AU  - Schroeder, Christopher
AU  - Mattern, Sven
AU  - Singer, Stephan
AU  - Bösmüller, Hans
AU  - Rammensee, Hans-Georg
AU  - Löffler, Markus W
AU  - Gouttefangeas, Cécile
TI  - Exceptional tumor-free survival of a patient with metastatic intrahepatic cholangiocarcinoma after surgery and personalized peptide vaccination: revisiting a striking case.
JO  - Journal for ImmunoTherapy of Cancer
VL  - 13
IS  - 10
SN  - 2051-1426
CY  - London
PB  - BioMed Central
M1  - DKFZ-2025-02068
SP  - e012107
PY  - 2025
AB  - Cholangiocarcinomas are rare but aggressive liver tumors of high lethality with scarce treatment options. Here we report on the follow-up of a patient diagnosed with an intrahepatic cholangiocarcinoma who experienced repeated tumor recurrences including distant metastasis, therefore facing a dismal prognosis. At present, this patient is tumor-free for more than 8 years following repeated surgery and application of two successive personalized vaccines. In-depth functional immune cell analyses revealed a dominant CD4+ T-cell response against the vaccine antigens with infiltration of the tumor site and immune responses prevailing for years following the last vaccine administration. Additionally, spontaneous tumor neoantigen-specific CD4+ and CD8+ T-cell responses have been detected, which might have contributed to the outstanding outcome witnessed in this patient. This case report highlights vaccination strategies targeting non-mutated antigens as well as the increasingly recognized central role of antitumor CD4+ T cells.
KW  - Humans
KW  - Cholangiocarcinoma: therapy
KW  - Cholangiocarcinoma: pathology
KW  - Cholangiocarcinoma: immunology
KW  - Cholangiocarcinoma: surgery
KW  - Bile Duct Neoplasms: therapy
KW  - Bile Duct Neoplasms: pathology
KW  - Bile Duct Neoplasms: immunology
KW  - Cancer Vaccines: therapeutic use
KW  - Male
KW  - Middle Aged
KW  - Precision Medicine: methods
KW  - Vaccines, Subunit: therapeutic use
KW  - Disease-Free Survival
KW  - CD4+T cells (Other)
KW  - cancer vaccine (Other)
KW  - case report (Other)
KW  - metastatic cholangiocarcinoma (Other)
KW  - Cancer Vaccines (NLM Chemicals)
KW  - Vaccines, Subunit (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:41067882
DO  - DOI:10.1136/jitc-2025-012107
UR  - https://inrepo02.dkfz.de/record/305222
ER  -