%0 Journal Article
%A Iyyappan Valsala, Praveen
%A Pohmann, Rolf
%A Heule, Rahel
%A Solomakha, Georgiy A
%A Avdievich, Nikolai I
%A Engelmann, Jörn
%A Kuebler, Laura
%A Martins, André
%A Scheffler, Klaus
%T High-resolution deuterium metabolic imaging of the human brain at 9.4 T using phase-cycled balanced SSFP spectral-spatial acquisitions.
%J Magnetic resonance in medicine
%V nn
%@ 1522-2594
%C New York, NY [u.a.]
%I Wiley-Liss
%M DKFZ-2025-02089
%P nn
%D 2025
%Z epub
%X The aim was to improve the sensitivity and robustness against B0 inhomogeneities of deuterium metabolic imaging (DMI) using phase-cycled balanced SSFP (bSSFP) methods at 9.4 T.We investigated two variants of phase-cycled bSSFP acquisitions, namely uniformly weighted multi-echo and acquisition-weighted chemical shift imaging (CSI) to improve the SNR of DMI in the brain after oral [6,6'-2H2]-glucose intake. Phase-cycling was introduced to reduce the off-resonance sensitivity of bSSFP, incurring a moderate SNR loss. Two SNR optimal methods for obtaining metabolite amplitudes from the phase-cycled bSSFP data were proposed. The SNR performance of the two bSSFP variants was compared with the SNR-optimized vendor's standard CSI. Additionally, in vivo T1 and T2 of deuterium metabolites were estimated.High-resolution whole-brain dynamic DMI maps were obtained for all acquisitions. The CSI variant of phase-cycled bSSFP achieved an average SNR increase of 16
%K IDEAL (Other)
%K SNR (Other)
%K bSSFP (Other)
%K deuterium metabolic imaging (Other)
%K ultra‐high‐field (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41078150
%R DOI:10.1002/mrm.70114
%U https://inrepo02.dkfz.de/record/305345