TY  - JOUR
AU  - Iyyappan Valsala, Praveen
AU  - Pohmann, Rolf
AU  - Heule, Rahel
AU  - Solomakha, Georgiy A
AU  - Avdievich, Nikolai I
AU  - Engelmann, Jörn
AU  - Kuebler, Laura
AU  - Martins, André
AU  - Scheffler, Klaus
TI  - High-resolution deuterium metabolic imaging of the human brain at 9.4 T using phase-cycled balanced SSFP spectral-spatial acquisitions.
JO  - Magnetic resonance in medicine
VL  - nn
SN  - 1522-2594
CY  - New York, NY [u.a.]
PB  - Wiley-Liss
M1  - DKFZ-2025-02089
SP  - nn
PY  - 2025
N1  - epub
AB  - The aim was to improve the sensitivity and robustness against B0 inhomogeneities of deuterium metabolic imaging (DMI) using phase-cycled balanced SSFP (bSSFP) methods at 9.4 T.We investigated two variants of phase-cycled bSSFP acquisitions, namely uniformly weighted multi-echo and acquisition-weighted chemical shift imaging (CSI) to improve the SNR of DMI in the brain after oral [6,6'-2H2]-glucose intake. Phase-cycling was introduced to reduce the off-resonance sensitivity of bSSFP, incurring a moderate SNR loss. Two SNR optimal methods for obtaining metabolite amplitudes from the phase-cycled bSSFP data were proposed. The SNR performance of the two bSSFP variants was compared with the SNR-optimized vendor's standard CSI. Additionally, in vivo T1 and T2 of deuterium metabolites were estimated.High-resolution whole-brain dynamic DMI maps were obtained for all acquisitions. The CSI variant of phase-cycled bSSFP achieved an average SNR increase of 16
KW  - IDEAL (Other)
KW  - SNR (Other)
KW  - bSSFP (Other)
KW  - deuterium metabolic imaging (Other)
KW  - ultra‐high‐field (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41078150
DO  - DOI:DOI:10.1002/mrm.70114
UR  - https://inrepo02.dkfz.de/record/305345
ER  -