%0 Journal Article
%A Wurschi, Georg
%A Kesselmeier, Miriam
%A Schneider, Melanie
%A Becker, Jan-Niklas
%A Frerker, Bernd
%A Vorbach, Samuel M
%A Ehret, Felix
%A Diefenhardt, Markus
%A Schunn, Fabian
%A von Gruben, Maria-Elena
%A Büttner, Marcel
%A Hoffmann, Elgin
%A Rühle, Alexander
%A Beier, Josephine
%A Ferdinandus, Simone
%A Trommer, Maike
%A Sahin, Ezgi Ceren
%A Hlouschek, Julian
%A Aninditha, Kynann
%A von Ohlen, Daphne Schepers
%A Kaufmann, Justus
%A Depardon, Alina
%A Ha, Hai Minh
%A Trommer, Simon
%A Kessler, Christopher
%A Cieslak, Adrianna
%A Fabian, Alexander
%A Rißner, Florian
%A Römer, Maximilian
%A Mäurer, Matthias
%A Pietschmann, Klaus
%T Short-course radiotherapy versus long-course chemoradiotherapy in total neoadjuvant therapy of rectal cancer - A multicenter analysis of early outcomes and toxicity.
%J Radiotherapy and oncology
%V 213
%@ 0167-8140
%C Amsterdam [u.a.]
%I Elsevier Science
%M DKFZ-2025-02093
%P 111194
%D 2025
%Z 2025 Dec;213:111194
%X Total neoadjuvant therapy (TNT) improves local control and complete response (CR) rates in locally advanced rectal cancer (LARC). CR is associated with favorable local tumor control, allowing non-operative management (NOM). However, it remains unclear whether short-course radiotherapy (SCRT) or long-course chemoradiotherapy (LCRT) is preferable within TNT.LARC patients undergoing TNT between 2015 and 2024 were included in this retrospective multicenter analysis (DRKS00033000). The primary endpoint was CR. Secondary endpoints comprised NOM rates, toxicity, and tumor control. Multivariable logistic regression modelling was used to assess the influence of LCRT.Of 295 included patients with a median age at diagnosis of 62 (Q1-Q3: 54-68) years and 210 (71.2 
%K Chemoradiotherapy (Other)
%K Complete response (Other)
%K Rectal cancer (Other)
%K Total neoadjuvant therapy (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41077142
%R 10.1016/j.radonc.2025.111194
%U https://inrepo02.dkfz.de/record/305349